Fluid Challenge Impact in the Portal Vein Pulsatility Depending on the Fluid Responsivness Status
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- Portal vein pulsatility index variation induced by the fluid challenge (%), defined by: Portal vein pulsatility index before the fluid challenge - portal vein pulsatility index after the fluid challenge.
研究概览
简要总结
Portal vein pulsatility index is a marker of venous congestion evaluated by point of care ultrasound. It is associated with acute kidney injury, especially in critically ill patients. It may be considered as a dynamic marker. The investigators hypothesized that portal vein pulsatility index is higher after a fluid challenge only in patient without preload dependence in critically ill patients with cardiovascular insufficiency.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •vasopressor requirement to maintain mean arterial pressure >65mmHg AND
- •at least one of the following criteria:
- •arterial lactate >2mmol/L;
- •capillary refill time >3s;
- •mottling score >1;
- •diuresis <0,5mL/h for more than 6hours.
排除标准
- •Diameter of vena cava <20mm
- •Cirrhosis
- •Pregnancy
- •Severe acute pulmonary edema
- •Phototype 4 or 5
- •Patient opposition to participate
结局指标
主要结局
Portal vein pulsatility index variation induced by the fluid challenge (%), defined by: Portal vein pulsatility index before the fluid challenge - portal vein pulsatility index after the fluid challenge.
时间窗: One hour
Portal vein pulsatility index is defined as the (maximal velocity - minimal velocity) / maximal velocity assessed with doppler in portal vein estimated with point of care ultrasound.
次要结局
未报告次要终点