Fluid Challenge Impact in the Portal Vein Pulsatility Depending on the Fluid Responsivness Status

Completed

• Conditions: Venous Congestion; Cardiovascular Insufficiency

• Registration Number: NCT05828407
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Portal vein pulsatility index is a marker of venous congestion evaluated by point of care ultrasound. It is associated with acute kidney injury, especially in critically ill patients. It may be considered as a dynamic marker. The investigators hypothesized that portal vein pulsatility index is higher after a fluid challenge only in patient without preload dependence in critically ill patients with cardiovascular insufficiency.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-03-16
• Study First Submitted QC: 2023-04-24
• Study First Posted: 2023-04-25
• Study Start: 2023-07-10
• Status Verified: 2024-06
• Primary Completion: 2024-06-03
• Study Completion: 2024-06-03
• Last Update Submitted: 2024-06-06
• Last Update Posted: 2024-06-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• vasopressor requirement to maintain mean arterial pressure >65mmHg AND

• at least one of the following criteria:

  • arterial lactate >2mmol/L;
  • capillary refill time >3s;
  • mottling score >1;
  • diuresis <0,5mL/h for more than 6hours.

Exclusion Criteria

• Diameter of vena cava <20mm
• Cirrhosis
• Pregnancy
• Severe acute pulmonary edema
• Phototype 4 or 5
• Patient opposition to participate

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Portal vein pulsatility index variation induced by the fluid challenge (%), defined by: Portal vein pulsatility index before the fluid challenge - portal vein pulsatility index after the fluid challenge.	One hour	Portal vein pulsatility index is defined as the (maximal velocity - minimal velocity) / maximal velocity assessed with doppler in portal vein estimated with point of care ultrasound.

Trial Locations

Locations (1)

Hôpital cardiologique Louis Pradel; 🇫🇷 Bron, France