NCT04429178已完成不适用
Portal Vein Pulsatility Flow in Pregnancy - a Pilot Study
University Hospital, Basel, Switzerland1 个研究点 分布在 1 个国家目标入组 80 人开始时间: 2020年8月13日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Portal vein pulsatility fraction (percent)
研究概览
简要总结
This study is to investigate if portal vein pulsatility fraction can be measured in pregnancy and if it increases during the course of pregnancy as would be expected by the physiologic increase in blood volume that happens during pregnancy. Portal vein pulsatility fraction is measured in non-pregnant controls and in women in the 1st, 2nd and 3rd trimester of pregnancy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Ability to give informed consent
- •American Society of Anesthesiologists (ASA) Class I and II
- •Singleton pregnancy during 1st, 2nd or 3rd trimester or healthy non-pregnant females of childbearing age as controls
排除标准
- •Inability to give informed consent
- •Multiple gestation
- •Significant co-morbidities (e.g. cardiac abnormalities, cardiac dysfunction, arrhythmias, severe asthma, renal insufficiency)
- •High risk pregnancies (e.g. pre-eclampsia, gestational hypertension, HELLP, gestational diabetes)
- •Body-Mass-Index (BMI) < 18kg/m2 or >40kg/m2
结局指标
主要结局
Portal vein pulsatility fraction (percent)
时间窗: single time-point at baseline
Portal vein pulsatility fraction (percent)
次要结局
- Hepatic venous flow (cm/sec)(single time-point at baseline)
- Right atrial and ventricular dimensions (cm)(single time-point at baseline)
- Inferior vena cava diameter (mm)(single time-point at baseline)
- Inferior vena cava collapsibility index (percent)(single time-point at baseline)
- Tricuspid Annular Plane Systolic Excursion (TAPSE) (mm)(single time-point at baseline)
研究者
研究点 (1)
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