Comparison of Bowel Cleansing Methods for Colonoscopy in Hospitalized Patients

• Conditions: Intestine; Complaints

• Registration Number: NCT01528098
• Lead Sponsor: Kangbuk Samsung Hospital

Brief Summary

The purpose of this study is to compare two regimens of polyethylene glycol(PEG) plus bisacodyl versus PEG alone for bowel preparation in hospitalized patients.

Detailed Description

Inadequate bowel preparation may lead to a longer colonoscopy, and to an inability to identify lesions. PEG can provide a rapid orthograde peroral approach to colonic lavage without producing significant fluid or electrolyte changes. Thus PEG is now commonly used for bowel preparation. However, large amounts and unsatisfactory taste of PEG solution are generally poorly tolerated, especially in hospitalized patients who had comorbidity and restricted ambulation. Recently, a new PEG-based bowel cleansing agents became available. It combines PEG with a high dose of ascorbic acid or bisacodyl. Although many studies reported the efficacy of these combined solution for colonoscopy, but efficacy in hospitalized patients was under-recognized.

Study Timeline

• Status Verified: 2012-02
• Study First Submitted: 2012-02-03
• Study First Submitted QC: 2012-02-03
• Study First Posted: 2012-02-07
• Last Update Submitted: 2012-02-20
• Last Update Posted: 2012-02-22
• Study Start: 2012-03
• Primary Completion: 2012-07
• Study Completion: 2012-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 600

Inclusion Criteria

• Hospitalized patients for colonoscopy

Exclusion Criteria

• age under 20 years or over 80 years
• major psychiatric illness
• known allergy to PEG
• serious condition- severe cardiac, renal, or metabolic diseases
• partial colon resection
• current acute exacerbation of chronic inflammatory bowel disease
• functional constipation defined by Rome III diagnostic criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The efficacy of bowel preparation	one day (after colonoscopy)	Ottawa scale

Secondary Outcome Measures

Name	Time	Method
Patient's compliance and acceptability	one day (after injestion of preparation solution)	acceptability, Visual Analogue Scale
Patient's compliance and acceptability (2)	one day (after injestion of preparation solution)	stress for ingestion, Stress 0(not) - 4(severe)
Patient's compliance and acceptability (3)	one day (after colonoscopy)	willingness for re-evaluation, 0(very willing) - 4(some)