Can polyethylene glycol solution be used as an alternative to lactulose in patients of hepatic encephalopathy ?
Phase 4
- Conditions
- Health Condition 1: F99- Mental disorder, not otherwise specified
- Registration Number
- CTRI/2024/02/062513
- Lead Sponsor
- I
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Patients with any grade of hepatic encephalopathy
(grade1-grade4)
2.Patients with chronic liver disease and acute on chronic liver failure of any cause.
Exclusion Criteria
patients with acute liver failure, suspected intestinal obstruction, pregnancy and lactation, uncontrolled infection and hemodynamically unstable and received more than 1 dose of lactulose prior to enrollment
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1 or more scale improvement in HE grades at 24 hours, 48 hours, 72 hours and at time of discharge using Hepatic Encephalopathy Scoring Algorithm (HESA) ranging from 0 to 4Timepoint: 12 months
- Secondary Outcome Measures
Name Time Method overall length of stay (LOS), serum ammonia concentration and time to HE resolution.Timepoint: 12 months