Association Between the Results of Specific Genetic Tests and the Efficacy of Targeted Therapies in Patients
Completed
- Conditions
- Non-small Cell Lung Cancer
- Registration Number
- NCT05450081
- Lead Sponsor
- Hunan Province Tumor Hospital
- Brief Summary
Our study aimed to evaluate the correlation between test reagent specific gene test results and the efficacy of relevant targeted drugs in patients with non-small cell lung cancer, and to support the continued registration of test reagents.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 140
Inclusion Criteria
- 1)≥18，advanced non-small cell lung cancer confirmed by histopathology, and were previously or currently treated with gefitinib tablets (as the first-line treatment) or osimertinib (first-generation TKI resistance treatment) or crizotinib capsules monotherapy were evaluated for efficacy.
-
- Able to provide FFPE samples with a storage life of 5 years: Large specimen 5 pieces in each case; 10 puncture specimens in each case
Exclusion Criteria
-
- Pathological evaluation of the tissue sample has too few tumor cells (total number of tumor cells >20%);
-
- Combination therapy with chemotherapy/radiotherapy/other targeted drugs/immunotherapy drugs;
-
- Maintenance treatment when the disease does not progress after other anti-tumor treatments.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Consistency October 2022-December 2022 he consistency of efficacy between specified kit and 22C3
PFS October 2022-December 2022 Progression free survival time
ORR October 2022-December 2022 Objective response rate
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Hunan Cancer hospital
🇨🇳Changsha, Hunan, China