Longitudinal Interaction Between APOA5 -1131T>C and Overweight Accelerates Arterial Stiffness

Completed

• Conditions: Overweight and Obesity
• Interventions: Genetic: rs662799 (APOA5 -1131T>C)

• Registration Number: NCT03367598
• Lead Sponsor: Yonsei University

Brief Summary

The aim of this study is to evaluate whether the longitudinal interaction between APOA5 -1131C variants and overweight could accelerate age-related increases in arterial stiffness and circulating triglycerides in healthy subjects.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-01-01
• Primary Completion: 2013-12-01
• Study Completion: 2013-12-31
• Status Verified: 2017-12
• Study First Submitted: 2017-12-04
• Study First Submitted QC: 2017-12-04
• Last Update Submitted: 2017-12-04
• Study First Posted: 2017-12-08
• Last Update Posted: 2017-12-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 503

Inclusion Criteria

• Nondiabetic (fasting serum glucose concentration < 126 mg/dL)
• Nonobese (BMI ≥ 25 kg/m2)

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Exclusion Criteria

• Current and/or past history of cardiovascular disease
• Diabetes mellitus (fasting glucose levels ≥126 mg/dL)
• Abnormal liver or renal function
• Thyroid or pituitary disease
• Pregnancy or lactation
• Regular use of any medication

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Overweight	rs662799 (APOA5 -1131T>C)	nondiabetic and nonobese individuals (25 kg/m2 ≤ BMI \< 30 kg/m2, n=154)
Normal weight	rs662799 (APOA5 -1131T>C)	nondiabetic and nonobese individuals (18.5 kg/m2 ≤ BMI \< 25 kg/m2, n=349)

Primary Outcome Measures

Name	Time	Method
Brachial-ankle PWV (baPWV)	3-year follow-up	cm/s

Secondary Outcome Measures

Name	Time	Method
Triglyceride	3-year follow-up	mg/dL