JPRN-UMIN000032775已完成未知
An observational study on interaction between 5ASA and thiopurine in ulcerative colitis - An observational study on interaction between 5ASA and thiopurine in ulcerative colitis
Kitasato University Kitasato Institute Hospital.0 个研究点目标入组 50 人开始时间: 2018年5月30日最近更新:
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 50
研究概览
简要总结
Results Plasma 5-ASA and N-Ac-5-ASA levels were significantly higher in patients receiving time-dependent mesalazine (n = 12) compared with pH-dependent mesalazine (n = 12) and MMX (n = 15), accompanied by greater TPMT inhibition. Prospective switching from time-dependent mesalazine to MMX decreased 6-TGN levels, increased those of 6-MMP, and increased 6-MMP/6-TGN ratios. Furthermore, this resulted in significantly more relapses than switching from pH-dependent mesalazine to MMX.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18years-old 至 ot applicable（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •Patients after total colonectomy Patients who are concurrently using uric acid synthesis inhibitors
研究者
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