A randomised controlled trial to compare the clinical effectiveness and safety of gentamicin and ceftriaxone in the treatment of gonorrhoea

niversity Hospital Birmingham NHS Foundation Trust (UK)0 个研究点目标入组 720 人开始时间: 2014年9月18日最近更新: 2021年12月27日

试验速览

2016 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/27881151 protocol 2019 Results article in https://www.ncbi.nlm.nih.gov/pubmed/31056291 results (added 08/05/2019) 2019 Results article in https://www.ncbi.nlm.nih.gov/pubmed/31099330 results (added 20/05/2019) 2020 Results article in https://pubmed.ncbi.nlm.nih.gov/32732336/ results (added 03/08/2020) 2020 Results article in https://pubmed.ncbi.nlm.nih.gov/32829308/ (added 15/12/2021)

•1. Aged 16-70 years
•2. Diagnosis of uncomplicated untreated genital, pharyngeal or rectal gonorrhoea based on a positive gram stained smear on microscopy, or positive NAAT
•3. Written informed consent provided

•1. Known concurrent bacterial sexually transmitted infection (apart from chlamydia)
•2. Known contraindications or allergy to gentamicin, ceftriaxone, azithromycin or lidocaine
•3. Pregnant or breastfeeding
•4. Current clinical diagnosis of complicated gonorrhoea infections eg pelvic inflammatory disease, epididymoorchitis
•5. Weight less than 40kg at the time of randomisation
•6. Currently receiving or have received ceftriaxone or gentamicin within the preceding 28 days
•7. Previous participation in this study

发起方

niversity Hospital Birmingham NHS Foundation Trust (UK)