Vein vs Arterial Grafts for Coronary Artery Bypass Grafting Surgery

Not Applicable

• Conditions: Angina Pectoris

• Registration Number: NCT02158455
• Lead Sponsor: Region Örebro County

Brief Summary

The investigators have developed a novel technique for saphenous vein graft harvesting for coronary artery bypass grafting (CABG) where the graft is harvested with a pedicle of surrounding tissue. A randomized trial has shown a significantly higher patency rate for vein grafts harvested with this new methode compared to conventional harvesting technique 8.5 years after surgery (90 vs 76 %). In 2004 the investigators started a prospective randomized trial comparing patency between vein grafts harvested with surrounding tissue and radial artery grafts. The result showed that vein grafts harvested with surrounding tissue had a significantly higher patency rate compared to radial artery grafts 3 years after surgery (98 vs 84 %). The present study is a long-term follow-up (8 years) of the patients included in the second randomized trial. The hypothesis is that vein grafts harvested with surrounding tissue have a significantly higher patency rate compared to radial artery grafts 8 years after surgery.

Detailed Description

Not available

Study Timeline

• Study Start: 2004-02
• Study First Submitted: 2014-04-30
• Status Verified: 2014-06
• Study First Submitted QC: 2014-06-04
• Last Update Submitted: 2014-06-04
• Study First Posted: 2014-06-06
• Last Update Posted: 2014-06-06
• Primary Completion: 2014-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 108

Inclusion Criteria

• Three vessel coronary artery disease

Exclusion Criteria

• 65 years or older
• Elevated creatinine
• Raynauds disease
• Vein stripping

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Graft patency	5 months	The grafts will be categorized as either "open" or "closed". A stenosis of the graft exceeding 70 % of the lumen diameter will be considered as "closed".

Trial Locations

Locations (1)

University hospital; 🇸🇪 Orebro, Sweden