Comparison Between the Saphenous Vein as Y-composite Graft Based on the Left Internal Thoracic Artery Versus Aortocoronary Conduit for Coronary Artery Bypass Grafting: A Prospective Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 290
- 试验地点
- 1
- 主要终点
- Graft patency
研究概览
简要总结
Left internal thoracic artery (LITA) has been acknowledged as the first graft of choice for coronary artery bypass grafting (CABG). However, it is still not conclusive which one is the best second graft of choice among right internal thoracic artery, radial artery, right gastroepiploic artery, saphenous vein, and etc., as well as its configuration for CABG.
In our institution, saphenous vein has been primarily used for the second graft and we have harvested it with 'No touch technique'. We have been demonstrated the excellent long-term patency of this 'No touch saphenous vein' in many studies. However, it is still unknown which configuration is the better strategy for the saphenous vein as a Y-composite graft based on the left internal thoracic artery versus an aortocoronary conduit. Thus, we aimed to evaluate morphologic change of saphenous vein graft by 1-year intravascular ultrasound (IVUS) study and angiographic patency results between Y-composite graft and aortocoronary conduit.
详细描述
The enrolled patient underwent routine sternotomy, and left internal thoracic artery (LITA) and saphenous vein (SV) are harvested. After harvest, the patient is randomized to Y-composite group or aortocoronary group.
For Y-composite group, SV is anastomosed to LITA as Y-composite fashion. Then, LITA is anastomosed to left anterior descending artery. SV is anastomosed to the rest of the target vessels with sequential anastomosis technique (e.g. diagonal branch, obtuse marginal branch, posterolateral branch and posterior descending artery).
For aortocoronary group, LITA is anastomosed to left anterior descending artery. Then, SV is anastomosed to ascending aorta using proximal anastomosis assist device without clamping the aorta. SV is anastomosed to the rest of the target vessels with sequential anastomosis technique (e.g. diagonal branch, obtuse marginal branch, posterolateral branch and posteriori descending artery).
At 1-year follow-up, coronary angiography is performed to evaluate the patency of the saphenous vein graft. Clinical outcomes are also evaluated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •A patient who is going to receive coronary artery bypass grafting
- •Older than 19 years
- •Coronary artery bypass grafting is going to be performed with left internal thoracic artery and saphenous vein graft
排除标准
- •Other concomitant procedures (e.g. valve or aorta surgery) is planned
- •Patients with severe comorbidities which limit the life expectancy of them below 1 year (e.g. terminal cancer)
- •Patients whose left internal thoracic artery or saphenous vein is not available due to the low quality, severe injury, or absence of the graft
- •Patients whose ascending aorta is not suitable to aortocoronary anastomosis (e.g. ascending aorta aneurysm, porcelain aorta)
- •Emergency operation
- •Patients who have connective tissue disease
- •Reoperative coronary artery bypass grafting
结局指标
主要结局
Graft patency
时间窗: at postoperative 1 year
Graft patency measured by coronary angiography
次要结局
- All-cause mortality(at postoperative 1 year)
- Cardiac death(at postoperative 1 year)
- Major Adverse Cardiac Events (MACEs)(at postoperative 1 year)
- Target vessel revascularization(at postoperative 1 year)
- Reintervention(at postoperative 1 year)
研究者
Ho Young Hwang
Professor
Seoul National University Hospital