Treatment with acetylcholine esterase inhibitors in anorexia nervosa : a multicenter double-blind randomised controlled trial versus placebo
- Conditions
- Anorexia nervosaTherapeutic area: Psychiatry and Psychology [F] - Mental Disorders [F03]
- Registration Number
- CTIS2024-511681-37-00
- Lead Sponsor
- Centre Hospitalier Sainte Anne Paris
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- Not specified
- Target Recruitment
- 111
female, Presence of 3 DSM V criteria for anorexia nervosa, Restrictive subtype of anorexia nervosa, Body Mass Index between 14 and 18.5 kg/m2, Aged between 18 and 65, Resting heart rate greater than or equal to 40 bpm
Past diagnosis of anorexia nervosa in the form of hyperphagia/purgation, Pregnant or breast-feeding women, Past diagnosis of bulimia nervosa, Past diagnosis of binge eating disorder, Comorbid diagnosis of psychotic disorder and/or bipolar disorder, Renal impairment (glomerular filtration rate less than 60 mL/min according to the MDRD formula), Liver failure or transaminase elevation greater than 5N, Electrocardiogram of conduction disorder, Taking a psychotropic drug now or in the three weeks prior to inclusion (including antidepressants, to avoid interaction/potentiation in this population), Taking a treatment involving the following cytochromes : P450, P3A4, P2D6
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method