Predictive Value of Glycocalyx Biomarkers in Mechanical Ventilation of Patients With ARDS for Clinical Prognosis and Long-term Pulmonary Fibrosis
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 336
- 试验地点
- 1
- 主要终点
- 28 days mortality from patients involved in the study
研究概览
简要总结
ARDS is a severe disease in ICU, and could induce high mortality. Glycocalyx is an important matrix construction which covers endothelial cells, it could protect endothelial cells injury and the glycocalyx biomarkers could predict pulmonary injury.
Decorin is a member of the small leucine-rich proteoglycan (SLRP) family, contains a single glycosaminoglycan (GAG) chain and a core protein with 12 leucine-rich repeats. In the previous study, decorin is associated with cardiac and liver fibrosis, however, the effects of decorin on ARDS pulmonary fibrosis have not been clarified.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age > 18yrs and <80yrs
- •Meet ARDS Berlin definition
- •With mechanical ventilation
排除标准
- •have chronic pulmonary disease
- •have use heparin or low molecular heparin or chondroitin sulfuric acid
结局指标
主要结局
28 days mortality from patients involved in the study
时间窗: 28 days
28 days mortality from patients involved in the study
次要结局
- pulmonary function test to evaluate pulmonary function(1mon, 3mon and 6 month)
- CT and syndecan-1 to evaluate pulmonary fibrosis(1mon, 3mon and 6 month)
研究者
Chun Pan
Principal Investigator
Southeast University, China