Glycocalyx Biomarkers in ARDS for Clinical Prognosis and Pulmonary Fibrosis
- Conditions
- Endothelial DysfunctionARDS, HumanMechanical Ventilation Pressure High
- Registration Number
- NCT03854565
- Lead Sponsor
- Southeast University, China
- Brief Summary
ARDS is a severe disease in ICU, and could induce high mortality. Glycocalyx is an important matrix construction which covers endothelial cells, it could protect endothelial cells injury and the glycocalyx biomarkers could predict pulmonary injury.
Decorin is a member of the small leucine-rich proteoglycan (SLRP) family, contains a single glycosaminoglycan (GAG) chain and a core protein with 12 leucine-rich repeats. In the previous study, decorin is associated with cardiac and liver fibrosis, however, the effects of decorin on ARDS pulmonary fibrosis have not been clarified.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 336
- Age > 18yrs and <80yrs
- Meet ARDS Berlin definition
- With mechanical ventilation
- have chronic pulmonary disease
- have use heparin or low molecular heparin or chondroitin sulfuric acid
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 28 days mortality from patients involved in the study 28 days 28 days mortality from patients involved in the study
- Secondary Outcome Measures
Name Time Method pulmonary function test to evaluate pulmonary function 1mon, 3mon and 6 month pulmonary function evaluated by pulmonary function test
CT and syndecan-1 to evaluate pulmonary fibrosis 1mon, 3mon and 6 month pulmonary fibrosis evaluated by biomarker and CT
Trial Locations
- Locations (1)
Zhongda Hospital, Southeast University
🇨🇳Nanjing, Jiangsu, China
Zhongda Hospital, Southeast University🇨🇳Nanjing, Jiangsu, ChinaChun Pan, DrContact+862583262550panchun1982@gmail.com