Evaluation of the Possible Relationship Between Preeclampsia and Periodontal Disease With Clinical Periodontal, Biochemical and Microbiological Data
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 试验地点
- 5
- 主要终点
- prostaglandin E2
研究概览
简要总结
The primary objective of the study is to assess the incidence and severity of the periodontal infection of patients with preeclampsia.
The secondary objective of the study is to analyze the relationship between preeclampsia and periodontal infection, using clinical, biochemical and microbiological methods.
详细描述
Preeclampsia is identified as an important cause for mother and newborn mortality. Inspite of extensive research, the exact etiological relations have not been established.
Periodontal disease is a subclinical and persistent infection source which induces the systemic inflammatory reactions and increases the risk of preeclampsia. It is believed that the results will set light to the etiology of preeclampsia and will help to develop strategies to prevent the disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 34 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •pregnant women with preeclampsia
- •weeks of pregnant women with no history of preterm labor
排除标准
- •Genitourinary infection,
- •pregnancy or pre-pregnancy hypertension,
- •HIV infection,
- •diabetes mellitus,
- •multiple pregnancy, preterm labor / low birth weight,
- •smoker and alcohol use history,
- •IVF pregnancy,
- •placental, cervical and uterine anomalies,
- •pregnancy with intrauterine growth retardation,
- •pregnancies with congenital or chromosomal fetal anomalies,
- •significant vaginal bleeding,
- •infertility stories,
- •drug addicts,
- •poor socioeconomic level
结局指标
主要结局
prostaglandin E2
时间窗: 1 Day
prostaglandin E2 levels will be evaulated in salivary, serum and placenta samples using ELISA test Normal value:29-97 pg / ml
IL-1beta (Interleukin 1 beta)
时间窗: 1 day
IL-1beta levels will be evaulated in salivary, serum and placenta samples using ELISA test Normal value:3-227pg/ml
TNF-Alpha (Tumor necrosis factor -Alpha)
时间窗: 1 day
TNF-Alpha levels will be evaulated in salivary, serum and placenta samples using ELISA test Normal value:42-203pg/ml
次要结局
- Tannerella Forsythia(1 Day)
- Porphyromonas gingivalis(1 Day)
研究者
Gul Yildiz Telatar
Principal Investigator
Recep Tayyip Erdogan University Training and Research Hospital