Evaluation of the Possible Relationship Between Preterm Labor and Periodontal Disease With Clinical Periodontal, Biochemical and Microbiological Data
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Preterm Labor
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
- Enrollment
- 100
- Locations
- 6
- Primary Endpoint
- TNF-Alpha
- Last Updated
- 7 years ago
Overview
Brief Summary
The primary objective of the study is to assess the incidence and severity of the periodontal infection of patients with preterm labor.
The secondary objective of the study is to analyze the relationship between preterm labor and periodontal infection, using clinical, biochemical and microbiological methods.
Detailed Description
Preterm infants are born prior to completion of 37 weeks of gestation. Periodontal disease is a subclinical and persistent infection source which induces the systemic inflammatory reactions and increases the risk of preterm labor. It is believed that the results will set light to the etiology of preterm labor and will help to develop strategies to prevent the disease.
Investigators
Gul Yildiz Telatar
Principal Investigator
Recep Tayyip Erdogan University Training and Research Hospital
Eligibility Criteria
Inclusion Criteria
- •pregnant women with preterm labor
- •weeks of pregnant women with no history of preterm labor
Exclusion Criteria
- •Genitourinary infection
- •pregnancy or pre-pregnancy hypertension
- •HIV infection
- •diabetes mellitus
- •multiple pregnancy, preterm labor / low birth weight
- •smoker and alcohol use history
- •IVF pregnancy
- •placental, cervical and uterine anomalies
- •pregnancy with intrauterine growth retardation
- •pregnancies with congenital or chromosomal fetal anomalies
Outcomes
Primary Outcomes
TNF-Alpha
Time Frame: 1 day
TNF-Alpha levels will be evaluated in salivary, serum and placenta samples using ELISA test Normal value:42-203pg/ml
prostaglandin E2
Time Frame: 1 Day
prostaglandin E2 levels will be evaluated in salivary, serum and placenta samples using ELISA test Normal value:29-97 pg / ml
IL-1beta
Time Frame: 1 day
IL-1beta levels will be evaluated in salivary, serum and placenta samples using ELISA test Normal value:3-227pg/ml
Secondary Outcomes
- Porphyromonas gingivalis(1 Day)
- Tannerella Forsythia(1 Day)