Comparison of Pre-operative EUS Guided and Intra-operative Direct Portal Vein Pressure Measurement in Pretransplant Cirrhotics

Not yet recruiting

• Conditions: Liver Cirrhosis

• Registration Number: NCT06114355
• Lead Sponsor: Asian Institute of Gastroenterology, India

Brief Summary

Direct portal pressure measurement under EUS-guidance (EUS-PPM) is a promising alternative to conventional indirect Hepatic Venous Pressure Gradient (HVPG). In patients undergoing liver transplantation for cirrhosis, high pre-operative portal vein (PV) pressure requires intra-operative portal vein inflow modulation (PIM). This pilot study aims to assess correlation between EUS-PPM with direct intra-operative portal pressure measurement (IO-PPM).

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-10
• Study First Submitted: 2023-10-28
• Study First Submitted QC: 2023-11-01
• Last Update Submitted: 2023-11-01
• Study First Posted: 2023-11-02
• Last Update Posted: 2023-11-02
• Study Start: 2023-12-01
• Primary Completion: 2024-12-01
• Study Completion: 2024-12-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• Liver cirrhosis patients scheduled for liver transplant for the standard indications within next 24- 48 hours will be included.

Exclusion Criteria

• Severe ascites not amenable for tapping
• History of blood thinner consumption within last 5 days
• Active duodenal ulcerations

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation between EUS-PPM with direct intra-operative portal pressure measurement (IO-PPM).	1 year	Correlation between EUS-PPM with direct intra-operative portal pressure measurement (IO-PPM).

Secondary Outcome Measures

Name	Time	Method
Correlation between readings of EUS-PPM using portable manometry set and arterial transducer.	1 year	Correlation between readings of EUS-PPM using portable manometry set and arterial transducer.