Endoscopic ultrasound (EUS)-guided portal pressure measurement in assessing the effectiveness of suboptimal beta-blocker dosing in primary variceal prophylaxis
Not Applicable
- Conditions
- CirrhosisOral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon
- Registration Number
- ACTRN12622000075785
- Lead Sponsor
- Royal Adelaide Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
1 - Ability to give informed consent
2 - Patient with Child A or B cirrhosis - on suboptimal doses of a beta-blocker for variceal primary prophylaxis:
(i) HR > 55bpm
(ii) Propranolol dose < 320mg daily but >= 80mg daily or Carvedilol < 12.5mg daily but >= 6.25mg daily
Exclusion Criteria
1 - Ischaemic heart disease or congestive cardiac failure
2 - Concurrent diagnosis of hepatocellular cancer
3 - Pregnant or breastfeeding women
4 - Creatinine clearance <60 mL/min
5 - Those whom investigators believe are unlikely to have more than 12 month’s life expectancy
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method