on-Invasive Portal and Hepatic Vein Pressure Estimation: MRI-Guided Diagnostics for Chronic Liver Disease

• Conditions: end-stage liver disease; liver cirrhosis; 10019654

• Registration Number: NL-OMON56118
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

- Eligable for liver transplantation (LT) screening
- Age >= 18 years and <= 75 (since >75 is a contraindication for LT)
- Written informed consent

Exclusion Criteria

- Exclusion criteria for MRI (claustrophobia, pacemaker, metal implants, etc.)
- A psychiatric, addictive or any other disorder that compromises the subjects
ability to understand the study content and to give written informed consent
for participation in the study

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The aim of the study is to compare non-invasive PH measurement by 4D flow MRI<br /><br>and CFD modelling with HVPG measurements<br /><br>using the transjugular approach in patients with end-stage liver disease<br /><br>screened for OLT.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary objectives are cost effectiveness, safety, feasibility and efficacy<br /><br>of 4D flow MRI and CFD modelling.</p><br>