Brain health in atrial fibrillatio

Not Applicable

Recruiting

• Conditions: Atrial Fibrillation; Dementia; Cardiovascular - Other cardiovascular diseases; Neurological - Dementias

• Registration Number: ACTRN12621000363886
• Lead Sponsor: niversity of Auckland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-03-31
• Last Update Posted: 27 June 2022

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Atrial fibrillation patients
•Chronic AF established on ECG or Holter monitoring
•Men and women
•Aged 18 years and over

A sub-set of atrial fibrillation patients will be studied before and after:
•A clinical decision (i.e., unrelated to the research study) to attempt restoration of sinus rhythm with cardioversion or by radiofrequency/ cryo-ablation has been taken.

Healthy sinus rhythm controls
•Healthy control subjects in sinus rhythm
•Not taking any prescription or over-the-counter medications (other than oral contraceptive pill)
•Men and women
•Aged 18 years and over

Exclusion Criteria

•<18 years old
•Normal contraindications for MRI (e.g., metallic implants)
•Current use of oral nitrates
•Hemodynamically significant valvular heart disease (e.g., stenosis, mechanical valve replacement)
•Severe left ventricular systolic dysfunction
•Recent acute coronary syndrome (<12 months) (e.g., MI, angioplasty, unstable angina)
•Severe respiratory disease (e.g., chronic obstructive pulmonary disease)
•Severe, uncontrolled type II diabetes (e.g., insulin dependent)
•Current cancer diagnosis or complete remission <5 years
•Connective tissue or inflammatory disease (e.g., rheumatoid arthritis, lupus)
•Neurological / psychiatric disease (e.g., stroke, TIA, dementia, Parkisnon’s)
•Current infection or pyrexial illness
•Uncontrolled thyroid disorders
•Hepatic or renal impairment (e.g., eGFR <60)
•Current pregnancy
•Current hormone replacement therapy
•Current user of recreational drugs
•Current abuser of alcohol
•Current smoker
•Body mass index < 18 kg/m2.
•Underlying medical conditions, which in the opinion of the Investigator place the participant at unacceptably high risk for participating in the study
•Inability to fully or appropriately participate in the study

Study & Design

• Study Type: Observational
• Study Design: Not specified