Auditory Perceptual and Memory Deficits in Congenital Amusia: Studies of Cerebral Correlates With MEG, Anatomical MRI and Functional MRI
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Hospices Civils de Lyon
- Enrollment
- 230
- Locations
- 2
- Primary Endpoint
- Neurophysiological tests MRI
Study Overview
Brief Summary
The project studies auditory deficits in congenital amusia at the behavioral and neurophysiological levels.
The auditory processes investigated are pitch discrimination, short-term memory, sound-induced emotions. To characterize auditory deficits in the amusic population, neuropsychological assessments are combined with neurophysiological markers (Electro-encephalography: EEG, Magneto-encephalography: MEG, Magnetic Resonance Imaging: MRI).
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 70 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Aged from 18 to 70 years' old
- •Compatibility IRM / MEG (no metal in the body)
- •Motivation to participate effectively in the project
- •No neurological or psychiatric history
- •No severe hearing loss
- •Informed consent to participate in the study
- •For Amusic participants: participant diagnosed amusic by the MBEA (Montreal Battery of Evaluation of Amusia)
- •For Control participants: matched in age, sex, education, music education, laterality, non-amusic (controlled with the MBEA)
Exclusion Criteria
- •Age below 18 or above 70
- •Non-Francophone volunteers.
- •MRI scanning not possible: artificial cardiac pacemaker, insulin pump, metallic prosthesis, intra-cerebral clip, claustrophobia
- •MEG acquisition not possible: large heads, neurostimulator, metal in the head or the body.
- •Pregnant or breast-feeding women
Arms & Interventions
Amusia
Since 2006, recruitment of amusia participants has been organized in the Lyon region, and some 20 participants (and their matched controls in terms of age, sex, laterality, musical practice, number of years of study) have already taken part various studies conducted at the CRNL. The recruitment of amusia participants and controls is continued in order to maintain a sufficient number of participants and compensate for the withdrawals within the cohort already constituted (lack of availability, geographical distance, etc.).
Intervention: Neuropsychological and neurophysiological tests (Other)
Amusia
Since 2006, recruitment of amusia participants has been organized in the Lyon region, and some 20 participants (and their matched controls in terms of age, sex, laterality, musical practice, number of years of study) have already taken part various studies conducted at the CRNL. The recruitment of amusia participants and controls is continued in order to maintain a sufficient number of participants and compensate for the withdrawals within the cohort already constituted (lack of availability, geographical distance, etc.).
Intervention: Experiment 1 (Other)
Amusia
Since 2006, recruitment of amusia participants has been organized in the Lyon region, and some 20 participants (and their matched controls in terms of age, sex, laterality, musical practice, number of years of study) have already taken part various studies conducted at the CRNL. The recruitment of amusia participants and controls is continued in order to maintain a sufficient number of participants and compensate for the withdrawals within the cohort already constituted (lack of availability, geographical distance, etc.).
Intervention: Experiment 2 (Other)
Amusia
Since 2006, recruitment of amusia participants has been organized in the Lyon region, and some 20 participants (and their matched controls in terms of age, sex, laterality, musical practice, number of years of study) have already taken part various studies conducted at the CRNL. The recruitment of amusia participants and controls is continued in order to maintain a sufficient number of participants and compensate for the withdrawals within the cohort already constituted (lack of availability, geographical distance, etc.).
Intervention: Experiment 3 (Other)
Amusia
Since 2006, recruitment of amusia participants has been organized in the Lyon region, and some 20 participants (and their matched controls in terms of age, sex, laterality, musical practice, number of years of study) have already taken part various studies conducted at the CRNL. The recruitment of amusia participants and controls is continued in order to maintain a sufficient number of participants and compensate for the withdrawals within the cohort already constituted (lack of availability, geographical distance, etc.).
Intervention: Experiment 4 (Other)
Matched controls
Matched controls of age, sex, laterality, musical practice, number of years of studies.
Intervention: Neuropsychological and neurophysiological tests (Other)
Matched controls
Matched controls of age, sex, laterality, musical practice, number of years of studies.
Intervention: Experiment 1 (Other)
Matched controls
Matched controls of age, sex, laterality, musical practice, number of years of studies.
Intervention: Experiment 2 (Other)
Matched controls
Matched controls of age, sex, laterality, musical practice, number of years of studies.
Intervention: Experiment 3 (Other)
Matched controls
Matched controls of age, sex, laterality, musical practice, number of years of studies.
Intervention: Experiment 4 (Other)
Outcomes
Primary Outcomes
Neurophysiological tests MRI
Time Frame: Day 1
MRI images
Neurophysiological tests EEG
Time Frame: Day 1
Event-Related Potentials (EEG)
Correct answers to the neuropsychological tests
Time Frame: Day 1
Percentages of correct responses
Neuropsychological tests reaction times
Time Frame: Day 1
Neuropsychological tests reaction times
Neurophysiological tests MEG
Time Frame: Day 1
Event-Related Fields (MEG)
Secondary Outcomes
No secondary outcomes reported