Maturation of Auditory Processing in Children With Dyslexia Compared to Average-reading Children

Completed

• Conditions: Dyslexia
• Interventions: Other: no intervention

• Registration Number: NCT02345876
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

The hypothesis of central auditory processing disorders has been advanced to explain the anomalies of the grapheme/phoneme combination in some dyslexia. These phonological disorders may be linked to abnormalities of the efferent (medial olivocochlear) system modulation and of cortical asymmetry. Indeed, the efferent system has an asymmetry in relation to handedness. Thus, in right-handed subject, it is predominant on the right side. In contrast, in the subject-handed dyslexic, the efferent system tends to be right-lateralized or non-lateralized. However, after an audio-visual training, normal lateralization can appear. This maturation of the efferent system lateralization during reading acquisition seems to have a particular profile in dyslexics with phonological disorder, especially if it is persistent. This finding allows to consider new prognostic evaluation and speech therapy rehabilitation in the dyslexic child.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2014-03-11
• Study First Submitted: 2014-12-09
• Study First Submitted QC: 2015-01-19
• Study First Posted: 2015-01-26
• Status Verified: 2019-07
• Primary Completion: 2019-07-03
• Study Completion: 2019-07-03
• Last Update Submitted: 2019-07-17
• Last Update Posted: 2019-07-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 161

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Normal reading children	no intervention	Longitudinal follow-up without intervention
Dyslexic children	no intervention	Longitudinal follow-up without intervention

Primary Outcome Measures

Name	Time	Method
Change of The Asymmetry Index of the efferent system at 2 years interval	Day 1 and then at least 2 years (± 4 weeks)	The change of the Asymmetry Index of the efferent system The Asymmetry Index is the difference between the equivalent attenuation measured on the right ear and the left ear. Evoked otoacoustic emissions were recorded monaurally at five stimulus intensities ranging from 57 to 69 dB SPL in 3 dB steps, in random presentation order, with and without contralateral acoustic stimulation consisting of 30 dBSPL continuous broadband noise (speech-like noise) produced by an audiometer

Secondary Outcome Measures

Name	Time	Method
Change in percentage of correctly repeated stimuli which have been heard in both ears (binaural integration with divided attention) or in one indicated ear (binaural separation with selective attention)	Day 1 and then at least 2 years (± 4 weeks)	Presentation of different speech material to both ears simultaneously
Change in the percentage of correct answers obtained during a speech perception test in silence and noise.	Day 1 and then at least 2 years (± 4 weeks)	Oral repetition of VCV
Change in the level of reading skill	Day 1 and then at least 2 years (± 4 weeks)	Behavioral measure

Trial Locations

Locations (3)

Service ORL CHU Montpied; 🇫🇷 Clermont-Ferrand, France

Service d'Audiologie et Explorations Orofaciales Centre de Référence des Troubles des Apprentissages; 🇫🇷 Lyon, France

Centre Hospitzlier Le Vinatier; 🇫🇷 Bron, France