Auditory Deficits in Congenital Amusia (AMUSIE CONGENITALE)

Not Applicable

Completed

• Conditions: Healthy; Amusia, Congenital

• Registration Number: NCT03094624
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

The project studies auditory deficits in congenital amusia at the behavioral and neurophysiological levels.

The auditory processes investigated are pitch discrimination, short-term memory, sound-induced emotions. To characterize auditory deficits in the amusic population, neuropsychological assessments are combined with neurophysiological markers (Electro-encephalography: EEG, Magneto-encephalography: MEG, Magnetic Resonance Imaging: MRI).

Detailed Description

Not available

Study Timeline

• Study Start: 2013-01-13
• Study First Submitted: 2017-03-20
• Study First Submitted QC: 2017-03-23
• Study First Posted: 2017-03-29
• Primary Completion: 2019-05-23
• Study Completion: 2019-05-23
• Status Verified: 2021-06
• Last Update Submitted: 2021-06-17
• Last Update Posted: 2021-06-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 230

Inclusion Criteria

• Aged from 18 to 70 years' old
• French
• Compatibility IRM / MEG (no metal in the body)
• Motivation to participate effectively in the project
• No neurological or psychiatric history
• No severe hearing loss
• Informed consent to participate in the study
• For Amusic participants: participant diagnosed amusic by the MBEA (Montreal Battery of Evaluation of Amusia)
• For Control participants: matched in age, sex, education, music education, laterality, non-amusic (controlled with the MBEA)

Exclusion Criteria

• Age below 18 or above 70
• Non-Francophone volunteers.
• MRI scanning not possible: artificial cardiac pacemaker, insulin pump, metallic prosthesis, intra-cerebral clip, claustrophobia
• MEG acquisition not possible: large heads, neurostimulator, metal in the head or the body.
• Pregnant or breast-feeding women

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Neurophysiological tests EEG	Day 1	Event-Related Potentials (EEG)
Correct answers to the neuropsychological tests	Day 1	Percentages of correct responses
Neuropsychological tests reaction times	Day 1	Neuropsychological tests reaction times
Neurophysiological tests MEG	Day 1	Event-Related Fields (MEG)
Neurophysiological tests MRI	Day 1	MRI images

Trial Locations

Locations (1)

Hospices Civils de Lyon, Hôpital Edouard Herriot; 🇫🇷 Lyon, France