Auditory Perceptual and Memory Deficits in Congenital Amusia: Studies of Cerebral Correlates With MEG, Anatomical MRI and Functional MRI
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 230
- 试验地点
- 2
- 主要终点
- Neurophysiological tests EEG
研究概览
简要总结
The project studies auditory deficits in congenital amusia at the behavioral and neurophysiological levels.
The auditory processes investigated are pitch discrimination, short-term memory, sound-induced emotions. To characterize auditory deficits in the amusic population, neuropsychological assessments are combined with neurophysiological markers (Electro-encephalography: EEG, Magneto-encephalography: MEG, Magnetic Resonance Imaging: MRI).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged from 18 to 70 years' old
- •Compatibility IRM / MEG (no metal in the body)
- •Motivation to participate effectively in the project
- •No neurological or psychiatric history
- •No severe hearing loss
- •Informed consent to participate in the study
- •For Amusic participants: participant diagnosed amusic by the MBEA (Montreal Battery of Evaluation of Amusia)
- •For Control participants: matched in age, sex, education, music education, laterality, non-amusic (controlled with the MBEA)
排除标准
- •Age below 18 or above 70
- •Non-Francophone volunteers.
- •MRI scanning not possible: artificial cardiac pacemaker, insulin pump, metallic prosthesis, intra-cerebral clip, claustrophobia
- •MEG acquisition not possible: large heads, neurostimulator, metal in the head or the body.
- •Pregnant or breast-feeding women
结局指标
主要结局
Neurophysiological tests EEG
时间窗: Day 1
Event-Related Potentials (EEG)
Correct answers to the neuropsychological tests
时间窗: Day 1
Percentages of correct responses
Neuropsychological tests reaction times
时间窗: Day 1
Neuropsychological tests reaction times
Neurophysiological tests MEG
时间窗: Day 1
Event-Related Fields (MEG)
Neurophysiological tests MRI
时间窗: Day 1
MRI images
次要结局
未报告次要终点