Auditory Deficits in Congenital Amusia (AMUSIE CONGENITALE)

Not Applicable

Completed

• Conditions: Healthy; Amusia, Congenital
• Interventions: Other: Neuropsychological and neurophysiological tests; Other: Experiment 1; Other: Experiment 2; Other: Experiment 3; Other: Experiment 4

• Registration Number: NCT03094624
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

The project studies auditory deficits in congenital amusia at the behavioral and neurophysiological levels.

The auditory processes investigated are pitch discrimination, short-term memory, sound-induced emotions. To characterize auditory deficits in the amusic population, neuropsychological assessments are combined with neurophysiological markers (Electro-encephalography: EEG, Magneto-encephalography: MEG, Magnetic Resonance Imaging: MRI).

Detailed Description

Not available

Study Timeline

• Study Start: 2013-01-13
• Study First Submitted: 2017-03-20
• Study First Submitted QC: 2017-03-23
• Study First Posted: 2017-03-29
• Primary Completion: 2019-05-23
• Study Completion: 2019-05-23
• Status Verified: 2021-06
• Last Update Submitted: 2021-06-17
• Last Update Posted: 2021-06-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 230

Inclusion Criteria

• Aged from 18 to 70 years' old
• French
• Compatibility IRM / MEG (no metal in the body)
• Motivation to participate effectively in the project
• No neurological or psychiatric history
• No severe hearing loss
• Informed consent to participate in the study
• For Amusic participants: participant diagnosed amusic by the MBEA (Montreal Battery of Evaluation of Amusia)
• For Control participants: matched in age, sex, education, music education, laterality, non-amusic (controlled with the MBEA)

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Exclusion Criteria

• Age below 18 or above 70
• Non-Francophone volunteers.
• MRI scanning not possible: artificial cardiac pacemaker, insulin pump, metallic prosthesis, intra-cerebral clip, claustrophobia
• MEG acquisition not possible: large heads, neurostimulator, metal in the head or the body.
• Pregnant or breast-feeding women

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Amusia	Experiment 4	Since 2006, recruitment of amusia participants has been organized in the Lyon region, and some 20 participants (and their matched controls in terms of age, sex, laterality, musical practice, number of years of study) have already taken part various studies conducted at the CRNL. The recruitment of amusia participants and controls is continued in order to maintain a sufficient number of participants and compensate for the withdrawals within the cohort already constituted (lack of availability, geographical distance, etc.).
Matched controls	Experiment 1	Matched controls of age, sex, laterality, musical practice, number of years of studies.
Amusia	Experiment 1	Since 2006, recruitment of amusia participants has been organized in the Lyon region, and some 20 participants (and their matched controls in terms of age, sex, laterality, musical practice, number of years of study) have already taken part various studies conducted at the CRNL. The recruitment of amusia participants and controls is continued in order to maintain a sufficient number of participants and compensate for the withdrawals within the cohort already constituted (lack of availability, geographical distance, etc.).
Matched controls	Neuropsychological and neurophysiological tests	Matched controls of age, sex, laterality, musical practice, number of years of studies.
Matched controls	Experiment 3	Matched controls of age, sex, laterality, musical practice, number of years of studies.
Matched controls	Experiment 4	Matched controls of age, sex, laterality, musical practice, number of years of studies.
Amusia	Neuropsychological and neurophysiological tests	Since 2006, recruitment of amusia participants has been organized in the Lyon region, and some 20 participants (and their matched controls in terms of age, sex, laterality, musical practice, number of years of study) have already taken part various studies conducted at the CRNL. The recruitment of amusia participants and controls is continued in order to maintain a sufficient number of participants and compensate for the withdrawals within the cohort already constituted (lack of availability, geographical distance, etc.).
Amusia	Experiment 3	Since 2006, recruitment of amusia participants has been organized in the Lyon region, and some 20 participants (and their matched controls in terms of age, sex, laterality, musical practice, number of years of study) have already taken part various studies conducted at the CRNL. The recruitment of amusia participants and controls is continued in order to maintain a sufficient number of participants and compensate for the withdrawals within the cohort already constituted (lack of availability, geographical distance, etc.).
Matched controls	Experiment 2	Matched controls of age, sex, laterality, musical practice, number of years of studies.
Amusia	Experiment 2	Since 2006, recruitment of amusia participants has been organized in the Lyon region, and some 20 participants (and their matched controls in terms of age, sex, laterality, musical practice, number of years of study) have already taken part various studies conducted at the CRNL. The recruitment of amusia participants and controls is continued in order to maintain a sufficient number of participants and compensate for the withdrawals within the cohort already constituted (lack of availability, geographical distance, etc.).

Primary Outcome Measures

Name	Time	Method
Neurophysiological tests MRI	Day 1	MRI images
Neurophysiological tests EEG	Day 1	Event-Related Potentials (EEG)
Correct answers to the neuropsychological tests	Day 1	Percentages of correct responses
Neuropsychological tests reaction times	Day 1	Neuropsychological tests reaction times
Neurophysiological tests MEG	Day 1	Event-Related Fields (MEG)

Trial Locations

Locations (1)

Hospices Civils de Lyon, Hôpital Edouard Herriot; 🇫🇷 Lyon, France