Correlation Between Peripheral Hearing Loss and Auditory Perception Impairment in Patients With Unilateral Sudden Deafness and Its Underlying Neural Mechanism
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Sudden Sensorineural Hearing Loss
- Sponsor
- Peking University People's Hospital
- Enrollment
- 10
- Primary Endpoint
- Change from Baseline Noisy speech recognition rate
- Status
- Not Yet Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
At present, few research on the auditory perception function and possible neural mechanisms of unilateral sudden hearing loss patients with complete or partial recovery of peripheral hearing.This project evaluate the speech perception function in noise of unilateral sudden hearing loss patients with with complete and partial hearing recovery by cognitive behavioral experiments, event-related potentials (ERPs) and functional magnetic resonance imaging (fMRI), and longitudinal follow-up to explore its underlying neural mechanisms.
Detailed Description
In clinical practice, many unilateral sudden hearing loss patients with complete and partial recovery of peripheral hearing still complain of hearing discomfort, especially difficulty in speech recognition in noisy environments. At present, there is still a lack of research on the auditory perception function and possible neural mechanisms of unilateral sudden hearing loss patients with complete or partial recovery of peripheral hearing. From the perspective of cognitive psychology, this project uses cognitive behavioral experiments, event-related potentials (ERPs) and functional magnetic resonance imaging (fMRI) to evaluate the reverberation environment of unilateral sudden hearing loss patients with complete and partial hearing recovery, and longitudinal follow-up to explore its underlying neural mechanisms. The investigators hope to understand the possible difficulties of binaural processing and auditory perception in patients with unilateral sudden deafness, and to explore the changes of central and cortical functions. This study not only has important guiding significance for the treatment and rehabilitation of patients with unilateral sudden deafness, but also expands the research group on auditory perception function and the psychological and neural mechanisms involved in binaural processing, which has important theoretical significance.
Investigators
Ma Xin
chief physician
Peking University People's Hospital
Eligibility Criteria
Inclusion Criteria
- •18-65 years old;
- •patients with unilateral idiopathic sudden sensorineural hearing loss (at least three adjacent frequencies of hearing loss ≥ 30 dB );
- •the first onset;
- •Contralateral hearing is normal; 5) Hearing is cured after treatment
Exclusion Criteria
- •Sudden deafness with possible definite etiology, such as Meniere's disease, large vestibular aqueduct syndrome, trauma, retrocochlear tumor, etc.;
- •Severe underlying diseases, heart disease, blood disease, pregnancy, breastfeeding, etc.;
- •Suffering from other central diseases that may affect speech perception disorders, such as Alzheimer's disease, etc.;
- •Those who cannot cooperate with the whole study inspection;
- •Those who do not agree to be enrolled or refuse to sign the informed consent form;
- •Those who are using may affect the Medications or treatments for speech perception disorders.
Outcomes
Primary Outcomes
Change from Baseline Noisy speech recognition rate
Time Frame: Change from Baseline Noisy speech recognition rate at admission，6 months, 12 months and 18 months after hearing recovery
The proportion of subjects correctly identifying the target sentence under different masking conditions and different signal-to-noise ratio conditions.