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Clinical Trials/NCT04999956
NCT04999956
Active, not recruiting
Not Applicable

Accuracy and Primary Stability in Immediate Implant Placement Using Dynamic Navigation or Freehand

Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University3 sites in 1 country24 target enrollmentJanuary 1, 2021
ConditionsTooth Diseases

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Tooth Diseases
Sponsor
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Enrollment
24
Locations
3
Primary Endpoint
Accuracy
Status
Active, not recruiting
Last Updated
2 years ago

Overview

Brief Summary

Prosthetic-driven immediate implant placement for optimal aesthetic restoration has been increasing in demand during the last decades but requires higher accuracy. Dynamic navigation has been reported better implant positioning. However, dynamic navigation's application to immediate implant placement has not been studied, and its exact role is still needed to be investigated further. Besides, implant insertion angle may influence primary stability, which is a prerequisite in achieving osseointegration, while dynamic navigation can precisely control angle and position. Therefore, the investigators designed a randomized controlled clinical trial study to verify the clinical efficacy of dynamic navigation and freehand in immediate implant placement. Patients will then be followed up one year after delivery of the crown to assess additional parameters.

Detailed Description

Prosthetic-driven immediate implant placement for optimal aesthetic restoration has been increasing in demand during the last decades but requires higher accuracy. Dynamic navigation has been reported better implant positioning. However, dynamic navigation's application to immediate implant placement has not been studied, and its exact role is still needed to be investigated further. Besides, implant insertion angle may influence primary stability, which is a prerequisite in achieving osseointegration, while dynamic navigation can precisely control angle and position. Therefore, the investigators designed a randomized controlled clinical trial study to verify the clinical efficacy of dynamic navigation and freehand in immediate implant placement. Patients will then be followed up one year after delivery of the crown to assess additional parameters. These will include the assessment of soft tissue inflammation, cytokine concentrations, microbiome, stability of the buccal bone plate.

Registry
clinicaltrials.gov
Start Date
January 1, 2021
End Date
July 31, 2023
Last Updated
2 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Responsible Party
Principal Investigator
Principal Investigator

Junyu Shi

Principal Investigator

Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

Eligibility Criteria

Inclusion Criteria

  • ≥18 years old and in good health;
  • The maxillary incisor that cannot be retained due to non-periodontitis;
  • The buccal bone plate is complete;
  • No acute infection;
  • The extraction socket have at least 3-5 mm apical bone.

Exclusion Criteria

  • General contraindications of oral implant surgery (such as immunodeficiency, long-term use of corticosteroids);
  • Treatments or diseases that may affect bone tissue metabolism (for example, taking bisphosphonates or receiving local radiotherapy);
  • Periodontitis history or uncontrolled periodontitis. Bleeding of probing (BOP) positive site ≥ 10%, or probing depth (PD) ≥ 4mm;
  • Heavy smokers or previous heavy smoking history (quit smoking time \<5 years or\> 20 cigarettes per day);
  • Refuse to participate in this trial.

Outcomes

Primary Outcomes

Accuracy

Time Frame: before surgery to after surgery one week

Taking cone-beam computed tomography (CBCT). The deviation between the planned implant and the actual implant were measured by Computer Assisted Dental Implant Precision System (Dcarer, Suzhou, China) as follows: (1) At least four feature points (like tooth cusps or bone pits) were selected in preoperative and postoperative CBCT for rough registration. (2) Feature surface circles in preoperative CBCT were selected, and then a mathematical algorithm displayed a similar feature surface circle in postoperative CBCT. The algorithm registered thousands of points in these two circles via conventional iso-surface thresholding technology. The software calculated registration error automatically. (3) Finally, the planned and actual implant were identified, and the deviation would be automatically calculated.

Peri-implant soft tissue health

Time Frame: 12-months follow-up after delivery of crown

Assessment of tissue health according to the definition of the 2017 International Classification. Berglundh et al.

Secondary Outcomes

  • Implant microbiome(12-months follow-up after delivery of crown)
  • Patient satisfaction(12-months follow-up after delivery of crown)
  • Esthetic appearance of the dental crown(12-months follow-up after delivery of the crown)
  • Peri-implant sulcus fluid Inflammation(12-months follow-up after delivery of crown)
  • Buccal bone changes(12-months follow-up after delivery of crown)
  • Insetion torque value (ITV)(surgery day)
  • Implant Stability Quotient (ISQ)(surgery day)

Study Sites (3)

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