SLeep and IMagery Correlates (SOMMEIL-IMAGERIE)

Not Applicable

Completed

• Conditions: Healthy

• Registration Number: NCT03130322
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

This study is designed to determine the neural networks underlying the sleep-related motor consolidation process following motor imagery practice. While beneficial effects of sleep are expected for sequential movement but not for adaptation motor tasks, the corresponding neuroanatomical correlates have not yet been investigated when participants acquired the motor tasks through mental practice. Data should substantially promote how designing motor imagery interventions targeting (re)learning and/or motor recovery in patients suffering from motor disorders.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-12-09
• Study First Submitted: 2017-03-10
• Study First Submitted QC: 2017-04-21
• Study First Posted: 2017-04-26
• Primary Completion: 2017-12-09
• Study Completion: 2018-07-04
• Status Verified: 2021-06
• Last Update Submitted: 2021-06-17
• Last Update Posted: 2021-06-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 51

Inclusion Criteria

• Healthy right-handed persons without neurologic disease
• Persons having signed informed consent for a neuroimagery study

Exclusion Criteria

• Persons under curatorship or any administrative/judicial measure
• Participants refusing to be informed of the results of the experiment
• Pregnant women
• Participants with contraindications to the MEG examination: head size, presence of a neurostimulator, steel pivot for the root canal, metallic fragments, ear implants, metal screws in the body or mouth.
• Persons using a pacemaker, insulin pump, or working regularly with iron filings
• Claustrophobic persons

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Evidence of MEG correlates of sleep motor consolidation (day 1)	Day 1 at 19h00 [post-training] (Groups 1, 2 and 3) OR Day 1 at 9h00 [post-training] (Group 4)	The investigator will use Single Aperture Magnetometry, i.e. a minimum variance beamformer mapping the spatial distribution of event-related desynchronizations and synchronizations within a predetermined frequency domain (Beta oscillations 15-35 Hz). The time course of MEG Beta power will be considered, and Granger causal connectivity analyses will be performed to investigate relationships between cortical motor regions.
Evidence of MEG correlates of sleep motor consolidation (day 2)	Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)	The investigator will use Single Aperture Magnetometry, i.e. a minimum variance beamformer mapping the spatial distribution of event-related desynchronizations and synchronizations within a predetermined frequency domain (Beta oscillations 15-35 Hz). The time course of MEG Beta power will be considered, and Granger causal connectivity analyses will be performed to investigate relationships between cortical motor regions.

Secondary Outcome Measures

Name	Time	Method
Accuracy of the motor tasks	Day 1 at 19h00 [post-training] (Groups 1, 2 and 3) OR Day 1 at 9h00 [post-training] (Group 4)	The investigators will measure the number of errors and correct trials for each motor task (finger sequential tasks OR motor adaptation task).
Time needed to complete the motor tasks (day 1)	Day 1 at 19h00 [post-training] (Groups 1, 2 and 3) OR Day 1 at 9h00 [post-training] (Group 4)	The investigators will measure the time needed to complete the motor tasks needed to complete each motor task (finger sequential tasks OR motor adaptation task).
Evidence of MEG correlates of sleep motor consolidation	Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)	The investigators will use Single Aperture Magnetometry, i.e. a minimum variance beamformer mapping the spatial distribution of event-related desynchronizations and synchronizations within a predetermined frequency domain (Beta oscillations 15-35 Hz). The time course of MEG Beta power will be considered, and Granger causal connectivity analyses will be performed to investigate relationships between cortical motor regions.
Time needed to complete the motor tasks	Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)	The investigators will measure the time needed to complete each motor task (finger sequential tasks OR motor adaptation task).
Accuracy of the motor tasks 2	Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)	The investigators will measure the number of errors and correct trials for each motor task (finger sequential tasks OR motor adaptation task).

Trial Locations

Locations (1)

CH le Vinatier; 🇫🇷 Bron, France