Systemic effects in patients with COPD; training or treatment

• Conditions: Chronic obstructive pulmonary disease; 10038716

• Registration Number: NL-OMON30383
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 42

Inclusion Criteria

clinically stable COPD patients (GOLD II, III, IV) with a low fat-free mass (<16 kg/m2 in men and <15 kg/m2 in women) and healthy volunteers

Exclusion Criteria

Exacerbation less than 2 months before the start of the experiment
Smoking
Oral corticosteroids
Long-term oxygen therapy
Respiratory insufficiency (PaO2 < 8 kPa or PaCO2 > 6,3 kPa)
Other chronic exercise limiting disorders

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Differences in parameters of systemic inflammation (concentrations of<br /><br>leukocyts, CRP, IL-6, IL-8, IL-1ra, TNFa) after intervention. Differences in<br /><br>parameters of oxidative stress (ROS-production, plasma antioxidant capacity,<br /><br>protein oxidation, lipid peroxidation, GSSG/GSH-ratio) after intervention.<br /><br>Differences in parameters of muscle damage (troponin I) after intervention.<br /><br>Differences in parameters of muscle breakdown (ubiquitin-proteasome system).<br /><br>Differences in pulmonary parameters and exercise capacity.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>-</p><br>