The effect of losartan/hydrochlorothiazide combination therapy on LV diastolic function in patients with uncontrolled hypertension in comparison with a high-dose losartan therapy
Phase 4
- Conditions
- hypertension
- Registration Number
- JPRN-UMIN000011959
- Lead Sponsor
- Tottori University Hospital
- Brief Summary
The combination therapy decreased BNP level, however, the high-dose losartan therapy did not. The combination therapy decreased E/E', however, the high-dose therapy did not. The combination therapy decreased MMP-2 level, however, the high-dose therapy did not.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 36
Inclusion Criteria
Not provided
Exclusion Criteria
LV systolic dysfunction (EF<50%) liver dysfunction (AST or ALT>=100) renal dysfunction (eGFR<30)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method E/E' in echocardiography, BNP
- Secondary Outcome Measures
Name Time Method MMP-2, MMP-9, TIMP-1, TIMP-2