Genetic- and Biological-Markers of Predisposition to Atherosclerosis: Leipzig-Heart Study

• Conditions: Atherosclerosis; Coronary Arteriosclerosis; Carotid Artery Diseases; Genetic Predisposition to Disease; Biological Markers

• Registration Number: NCT00497887
• Lead Sponsor: University of Leipzig

Brief Summary

Atherosclerotic cardiovascular disease is the major cause of morbidity and mortality in Western societies. It is a complex genetic disorder with many genes involved and significant gene-environment interactions. The aim of the study is to identify novel genetic- and biological-markers of atherosclerosis. Atherosclerosis is assessed in the coronary arteries using coronary angiography as well as in the carotid artery (intima-media-thickness) and peripheral vessels (ankle brachial index). Association analysis of genetic and metabolic markers with atherosclerotic burden will be performed to identify novel factors of disposition to atherosclerotic vascular disease.

Detailed Description

Not available

Study Timeline

• Study Start: 2006-12
• Study First Submitted: 2007-07-06
• Study First Submitted QC: 2007-07-06
• Study First Posted: 2007-07-09
• Status Verified: 2010-01
• Last Update Submitted: 2010-10-18
• Last Update Posted: 2010-10-19

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 4000

Inclusion Criteria

• Patients assigned to coronary angiography

Exclusion Criteria

• Cancer
• Acute myocardial infarction
• Inability to give informed consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (2)

University of Leipzig, Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics; 🇩🇪 Leipzig, Germany

University of Leipzig, Heart Center, Department of Cardiology; 🇩🇪 Leipzig, Germany