Evaluation of Catheter Placement for Renal Replacement Therapy in Patients With Acute Kidney Injury

Completed

• Conditions: Acute Kidney Injury

• Registration Number: NCT02200120
• Lead Sponsor: Brigham and Women's Hospital

Brief Summary

The purpose of this study is to examine the placement, timing, associated complications, efficacy of temporary and tunneled catheters for renal replacement therapy in patient with acute kidney injury.

Detailed Description

The purpose of this study is to examine the placement, timing, associated complications, efficacy of temporary and tunneled catheters for renal replacement therapy in patient with acute kidney injury. In particular, we will be assessing renal replacement adequacy for patients on dialysis and continuous veno-venous hemofiltration by monitoring urea reduction ratios, venous and arterial pressures. We will also be monitoring infection rates. We will compare these outcomes in patients receiving tunneled catheters and patients receiving temporary catheters.

Study Timeline

• Study Start: 2013-01
• Study First Submitted: 2014-07-21
• Study First Submitted QC: 2014-07-23
• Study First Posted: 2014-07-25
• Primary Completion: 2015-06
• Study Completion: 2015-06
• Status Verified: 2015-07
• Last Update Submitted: 2015-07-20
• Last Update Posted: 2015-07-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• Patients admitted to the hospital with acute kidney injury requiring renal replacement therapy

Exclusion Criteria

• End stage renal disease
• Chronic kidney disease 5 progression to end stage renal disease
• Outside hospital catheter placement

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Dialysis adequacy	up to 7d after starting renal replacement therapy	Adequacy will be measured using urea reduction ratio for patients on intermittent hemodialysis. For continuous renal replacement therapy, we will record the maximum blood flow rate achievable. These measurements/recordings will be made on average within 1-3 days of starting therapy.

Secondary Outcome Measures

Name	Time	Method
blood stream infection rates	within 30d of catheter placement	Patients will be followed throughout their hospitalization, which can range from a few days to several weeks. Bloodstream infections within 30d of catheter placement will be recorded.

Trial Locations

Locations (1)

Brigham and Women's Hospital; 🇺🇸 Boston, Massachusetts, United States