Influence of Vitamin D Supplementation on Serum BDNF Level and Cognitive Function in Schizophrenia
- Registration Number
- NCT03284294
- Lead Sponsor
- Universitas Padjadjaran
- Brief Summary
The objective of the study is to evaluate the influence of vitamin D supplementation on Serum Brain Derived Neurotrophic Factor level and cognitive function in schizophrenia treated with atypical antipsychotic. Methods: The investigator will use randomized controlled trial design. 40 chronic schizophrenia patients with vitamin D insufficiency or deficiency treated with atypical antipsychotic, will be randomly assign (1:1 ratio) to receive either daily oral cholecalciferol 2000 IU or placebo for 8 weeks. Assessment of BDNF serum and cognitive function will be performed at baseline and after 8 weeks period.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Male
- Target Recruitment
- 40
Inclusion Criteria
- Chronic schizophrenia
- Serum 25(OH)D level below 30 ng/ml
- Deficit in cognitive functions
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Exclusion Criteria
- Hypercalcemia
- Hepatic or renal failure
- Obese
- Metabolic syndrome
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo Oral placebo daily for 8 weeks Vitamin D Cholecalciferol Vitamin D Cholecalciferol 2000 IU oral daily for 8 weeks
- Primary Outcome Measures
Name Time Method Cognitive Function At the end of week 8 cognitive function as measured with standard cognitive battery
- Secondary Outcome Measures
Name Time Method BDNF serum level At the end of week 8 BDNF serum level as measured with ELISA method