Hidden transmission routes and attitudes towards sleeping sickness in Nigeria

Not Applicable

• Conditions: Attitudes and knowledge of Human African Trypanosomiasis (HAT), and the contribution of silent carriers and maternal transmission of HAT in Nigeria; Infections and Infestations

• Registration Number: ISRCTN15318880
• Lead Sponsor: Accord (United Kingdom)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2024-02-07
• Last Update Posted: 19 February 2024
• Study Completion: 2024-03-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

1. Willing and able to provide written informed consent
2. Individuals aged 18 years and above and residing in the study area for the questionnaire aspect of the study
3. Individuals over the age of 1 years old and residing in the study area for the blood sampling aspect of the study
4. Previously tested positive or are related to primary case from prior study
5. Key Informants which will include Ministerial officials, local government policymakers, non-governmental organizations, WHO or FAO representatives in Nigeria, and key academic research contacts

Exclusion Criteria

1. Unwillingness or unable to provide consent
2. Failure to establish relatedness primary case
3. Individuals aged less than 18 years for the questionnaire aspect of the study
4. Individuals less than 1 years old for the blood sampling aspect of the study

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Individuals test positive or negative for HAT measured using the standard protocols for Card Agglutination Trypanosomiasis Test (CATT) within 24 hours of sample collection or by PCR within 1 year of sample collection

Secondary Outcome Measures

Name	Time	Method
1. Number of asymptomatic carriers assessed by the number of positive individuals with no symptoms measured using CATT within 24 hours of sample collection or PCR within 1 year of sample collection<br>2. Maternal transmission cannot be assured but suspected if multiple family members test positive measured using CATT within 24 hours of sample collection or PCR within 1 year of sample collection<br>3. Attitudes and knowledge of HAT measured using a questionnaire and focus group on the same day as sample collection<br>4. Knowledge of the impact of COVID-19 on neglected tropical diseases in Nigeria ascertained by interview of policymakers at baseline<br><br>