ACTRN12620001108909
Not yet recruiting
未知
Impact of a shorter (7 days) compared with a longer (14d) duration of antimicrobial therapy on the treatment of bacteraemic urinary sepsis, measured by microbiological success after the completion of therapy: A sub-study of the BALANCE study.
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- rinary tract infection
- Sponsor
- Monash University
- Enrollment
- 284
- Status
- Not yet recruiting
- Last Updated
- 5 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\)The participant has been enrolled and randomised in the BALANCE study
- •2\)The source of bacteraemia is most likely to originate from the urinary tract as evidenced by:
- •a.The enrolling clinician believes that the urinary tract is the ‘most likely’ source of the bacteraemia
- •b.Routine clinical work\-up has not identified another ‘probable’ source of the bacteraemia
- •3\)The participant has a urine microscopy and culture result on a fresh urine sample (not from the drainage bag of a urinary catheter) supporting the urinary tract as a source of bacteraemia as evidenced by the presence of A \& B:
- •a.The urine culture has been collected during the same episode of acute illness associated with the bacteraemia.
- •b.Microbiological findings are supportive of a urinary source. An acceptable supportive result is ANY of the three criteria below:
- •i.A urine culture has isolated the same bacteria (genus \& species) as the blood culture. The antimicrobial resistance phenotype (antibiotic susceptibility pattern) may vary from the blood isolate.
- •ii.A urine culture has isolated mixed bacteria for which individual species have not been characterised
- •iii.A urine culture collected after antimicrobial therapy demonstrates a WCC count consistent with a urinary source of sepsis, based on local interpretation guidelines
Exclusion Criteria
- •1\)Male participants with suspected or confirmed prostatitis
- •2\)Participants with an Ileal loop or vesicoureteric reflux
- •3\)Participants who are unable or unwilling to provide a follow\-up urine sample for culture within the specified study time\-frame.
Outcomes
Primary Outcomes
Not specified
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