Pilot Investigation on the Health Benefits of Sub Acute (12 Week) Whole-body Vibration Training
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Change in VO2 Peak
研究概览
简要总结
The overall goals of this pilot investigation are to determine 1) the feasibility of conducting home based WBV studies, and 2) to determine if sub-acute home based WBV can improve a) exercise capacity, b) conduit- and micro- vascular function, and c) skeletal muscle function.
详细描述
Cardiovascular disease (CVD) is the leading cause of death in the world and many comorbid conditions (i.e. diabetes, obesity) can affect overall CVD risk. There is increasing interest into the role that skeletal muscle health plays in mediating CVD risk, particularly in metabolic disease states (ie. obesity and diabetes). Whole body vibration (WBV) has emerged as an exercise mimetic that may be more tolerable than traditional modes of exercise, such as treadmill walking/running or cycling. Similar to traditional exercise modalities, WBV can elicit beneficial metabolic effects. In fact, a single bout of WBV increases circulating concentrations of IL-6, which correspond with the normalization of glucose and insulin in obese individuals. The proposed pilot investigation will provide the foundation to begin understanding the molecular and physiological mechanisms of how sub-acute WBV can improve overall CVD risk. We hypothesize that home based WBV will decrease CVD risk by improving skeletal muscle and vascular function via a decrease in systemic inflammation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and women (> 18 yrs old)
- •All races
排除标准
- •<18 years old
- •Clinical diagnosis of hepatic, cardiovascular, or renal disease
- •Diabetic complications (i.e. macrovascular, microvascular, or autonomic)
- •Pregnancy
- •Direct vasoactive medications (i.e. nitrates)
结局指标
主要结局
Change in VO2 Peak
时间窗: pre-treatment baseline and following 12 weeks sub-acute whole-body vibration
change from baseline relative (mL/kg/min) peak oxygen consumption (VO2) during maximal exercise test at 12 weeks
Change in Flow-Mediated Dilation (FMD)
时间窗: pre-treatment baseline and following 12 weeks sub-acute whole-body vibration
change from baseline brachial artery flow mediated dilation at 12 weeks.
Change in Skeletal Muscle Mitochondrial Function
时间窗: pre-treatment baseline and following 12 weeks sub-acute whole-body vibration
change from baseline skeletal muscle mitochondrial function at 12 weeks. Measured using Near Infrared Spectroscopy (NIRS). Values are an index of phosphocreatine recovery expressed as a rate constant (min-1)
Change in Pulse Wave Velocity (PWV)
时间窗: pre-treatment baseline and following 12 weeks sub-acute whole-body vibration
Change from baseline PWV at 12 weeks. Measured by Shygmocor Xcel in m/s.
Change in Post Occlusive Reactive Hyperemia (PORH)
时间窗: pre-treatment baseline and following 12 weeks sub-acute whole-body vibration
Change from baseline PORH at 12 weeks. Measured by Laser Speckle Contrast Imager (Moor FLPI).
Change in IL-6
时间窗: pre-treatment baseline and following 12 weeks sub-acute whole-body vibration
change from baseline concentrations of Interleukin 6 (IL-6) obtained via blood draw at 12 weeks.
次要结局
未报告次要终点