Health Benefits of Whole-body Vibration

Not Applicable

Recruiting

• Conditions: Whole-body Vibration
• Interventions: Other: Sub Acute Whole Body Vibration Training

• Registration Number: NCT05097885
• Lead Sponsor: Augusta University

Brief Summary

The overall goals of this pilot investigation are to determine 1) the feasibility of conducting home based WBV studies, and 2) to determine if sub-acute home based WBV can improve a) exercise capacity, b) conduit- and micro- vascular function, and c) skeletal muscle function.

Detailed Description

Cardiovascular disease (CVD) is the leading cause of death in the world and many comorbid conditions (i.e. diabetes, obesity) can affect overall CVD risk. There is increasing interest into the role that skeletal muscle health plays in mediating CVD risk, particularly in metabolic disease states (ie. obesity and diabetes). Whole body vibration (WBV) has emerged as an exercise mimetic that may be more tolerable than traditional modes of exercise, such as treadmill walking/running or cycling. Similar to traditional exercise modalities, WBV can elicit beneficial metabolic effects. In fact, a single bout of WBV increases circulating concentrations of IL-6, which correspond with the normalization of glucose and insulin in obese individuals. The proposed pilot investigation will provide the foundation to begin understanding the molecular and physiological mechanisms of how sub-acute WBV can improve overall CVD risk. We hypothesize that home based WBV will decrease CVD risk by improving skeletal muscle and vascular function via a decrease in systemic inflammation.

Study Timeline

• Study First Submitted: 2021-10-15
• Study First Submitted QC: 2021-10-27
• Study First Posted: 2021-10-28
• Study Start: 2022-02-28
• Status Verified: 2023-09
• Last Update Submitted: 2023-09-20
• Last Update Posted: 2023-09-22
• Primary Completion: 2025-01-01
• Study Completion: 2026-01-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Men and women (> 18 yrs old)
• All races

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Exclusion Criteria

• <18 years old
• Clinical diagnosis of hepatic, cardiovascular, or renal disease
• Diabetic complications (i.e. macrovascular, microvascular, or autonomic)
• Pregnancy
• Direct vasoactive medications (i.e. nitrates)

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Sub Acute (12 week) Whole Body Training	Sub Acute Whole Body Vibration Training	-

Primary Outcome Measures

Name	Time	Method
Change in VO2 Peak	pre-treatment baseline and following 12 weeks sub-acute whole-body vibration	change from baseline relative (mL/kg/min) peak oxygen consumption (VO2) during maximal exercise test at 12 weeks
Change in Flow-Mediated Dilation (FMD)	pre-treatment baseline and following 12 weeks sub-acute whole-body vibration	change from baseline brachial artery flow mediated dilation at 12 weeks.
Change in Skeletal Muscle Mitochondrial Function	pre-treatment baseline and following 12 weeks sub-acute whole-body vibration	change from baseline skeletal muscle mitochondrial function at 12 weeks. Measured using Near Infrared Spectroscopy (NIRS). Values are an index of phosphocreatine recovery expressed as a rate constant (min-1)
Change in Pulse Wave Velocity (PWV)	pre-treatment baseline and following 12 weeks sub-acute whole-body vibration	Change from baseline PWV at 12 weeks. Measured by Shygmocor Xcel in m/s.
Change in Post Occlusive Reactive Hyperemia (PORH)	pre-treatment baseline and following 12 weeks sub-acute whole-body vibration	Change from baseline PORH at 12 weeks. Measured by Laser Speckle Contrast Imager (Moor FLPI).
Change in IL-6	pre-treatment baseline and following 12 weeks sub-acute whole-body vibration	change from baseline concentrations of Interleukin 6 (IL-6) obtained via blood draw at 12 weeks.

Trial Locations

Locations (1)

Augusta University/Georgia Prevention Institute/ Laboratory of Integrative and Exercise Physiology; 🇺🇸 Augusta, Georgia, United States