The Impact of Gut Microbiota in Anastomoses Insufficiency After Resection and Direct Anastomosis for Colorectal Cancer.
Completed
- Conditions
- Colorectal Cancer, Peritoneal Carcinomatosis, Anastomosis Insufficiency
- Interventions
- Procedure: Colectomy, CRS+HIPEC
- Registration Number
- NCT04252560
- Lead Sponsor
- Uppsala University Hospital
- Brief Summary
The role of gut microbiota in anastomosis insufficiency in patients operated for colorectal cancer and for peritoneal carcinomatosis is going to be investigated. This is a pilot study.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 45
Inclusion Criteria
Not provided
Exclusion Criteria
- Ongoing antibiotics treatment
- antibiotics treatment in the last 6 months
- acute surgery
- palliative surgery
- Ulcerös colitis or Crohns disease
- Prior colectomy
- Small intestine stoma before the operation
- neoadjuvant treatment
- Colon preparation
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description HIPEC Colectomy, CRS+HIPEC 15 patients operated with CRS+HIPEC for peritoneal carcinomatosis Colorectal Colectomy, CRS+HIPEC 30 patients operated for colorectal cancer
- Primary Outcome Measures
Name Time Method Microbiome 30 days Change in microbiome in case of insufficiency of the anastomosis
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Uppsala University Hospital
🇸🇪Uppsala, Sweden