Heparin-binding Protein (HBP) and Lungedema in ICU Patients. Is There a Correlation Between HBP and Pulmonary Vascular Permeability? A Prospective Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Correlation of Heparin-Binding Protein (HBP) and pulmonary vascular permeability Index (PVPI)
研究概览
简要总结
The goal of this single center observational cohort study is to investigate the relationship between physiological measures of lung oedema, and the biomarker Heparin-binding Protein (HBP).
The main questions it aims to answer are:
- Does the concentration of HBP in plasma correlate with measures of lung vascular permeability and extravascular water in the lungs?
- Does the concentration of HBP in plasma correlate with the patient's total accumulated fluid balance?
Researchers will collect blood samples and gather information on lung vascular permeability and extravascular lung water in Intensive care patients who are provided with a hemodynamic surveillance system called PiCCO. The study will include 25 patients.
详细描述
Abbreviations used:
HBP - Heparin-Binding Protein
PiCCO - Pulse Index Contour Continuous Cardiac Output
TPDT - Transpulmonary Thermodilution Technique
ICU - Intensive Care Unit
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients >18 years
- •Monitored with a PiCCO system
排除标准
- •Patients transferred from another ICU
研究组 & 干预措施
Intensive Care patients monitored with a PiCCO
结局指标
主要结局
Correlation of Heparin-Binding Protein (HBP) and pulmonary vascular permeability Index (PVPI)
时间窗: Patients are included in the study for as long as the PICCO monitoring is connected but with a maximum of three days.
The primary outcome is the correlation between concentration of HBP in plasma and PVPI. These values will be visualised using scatterplots with corresponding correlation coefficients. The statistical work up will include a Mann Whitney U test comparing the mean PVPI in the group of patients with HBP above median and the group of patients with HBP below median. Further statistics will include regression analysis depending on the nature of the results.
次要结局
- The correlation between mean HBP for each patient and total fluid balance.(From enrollment through study completion, a maximum of five days.)