Comparative Evaluation of the Effect of Different Adjunctive Air Polishing Powders in Nonsurgical Periodontal Therapy in Patients with Stage II and III Periodontitis

Not Applicable

• Conditions: Periodontitis

• Registration Number: NCT06726902
• Lead Sponsor: Diana Ibrahim

Brief Summary

The aim of this clinical trial is to evaluate and compare the effect of a newly designed air-polishing device (APD) using Erythritol, Glycine, and Trehalose air-polishing powders in nonsurgical periodontal therapy with control (conventional scaling and root planning) following the concept of guided biofilm therapy (GBT) as an adjunctive to subgingival instrumentation (SI) in nonsurgical periodontal therapy for Stage II and III periodontitis patients both clinically and microbiologically.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-03-03
• Primary Completion: 2024-11-01
• Status Verified: 2024-12
• Study Completion: 2024-12
• Study First Submitted: 2024-12-06
• Study First Submitted QC: 2024-12-06
• Last Update Submitted: 2024-12-09
• Study First Posted: 2024-12-10
• Last Update Posted: 2024-12-12

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 56

Inclusion Criteria

1. Individuals of both sexes with an age between 30 and 65 years, having at least 16 natural teeth in function,
2. Stage II and III (moderate to severe) periodontitis, having at least 16 teeth with the need for SI
3. Interproximal plaque index (API) ≤ 35%; patients with Good oral hygiene.
4. No history of systemic disease that may influence periodontal disease

Exclusion Criteria

1. Pregnancy or breastfeeding,
2. Smokers with more than seven cigarettes per day
3. Patients that had a treatment with antibiotics within six months before the study
4. Need for periodontal surgery or adjunctive antibiotic treatment to the SI
5. Patients who had any periodontal treatment during the last year before the study.
6. Patients with known systemic or autoimmune disease.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Bleeding on probing	up to six months
Pain Assessment	up to six months	Pain level will be assed using Visual Analogue Scale (VAS) from 1 (minimum) to 10 (maximum)
Probing depth	up to six months
Plaque accumulation	up to six months
Clinical attachment level	up to six months
Microbiological Assessment of Aggregatibacter actinomycetemcomitans (Aa)	one month
Microbiological Assessment of Porphyromonas gingivalis (Pg)	one month
Microbiological Assessment of Tannerella forsythia (Tf)	one month
Microbiological Assessment of Treponema denticola (Td)	one month

Trial Locations

Locations (1)

Faculty of Dentistry, Alexandria University; 🇪🇬 Alexandria, Egypt