Comparative Evaluation of the Effect of Different Adjunctive Air Polishing Powders in Nonsurgical Periodontal Therapy in Patients with Stage II and III Periodontitis: (A Randomized Controlled Clinical Trial)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Periodontitis
- Sponsor
- Diana Ibrahim
- Enrollment
- 56
- Locations
- 1
- Primary Endpoint
- Bleeding on probing
- Status
- Enrolling By Invitation
- Last Updated
- last year
Overview
Brief Summary
The aim of this clinical trial is to evaluate and compare the effect of a newly designed air-polishing device (APD) using Erythritol, Glycine, and Trehalose air-polishing powders in nonsurgical periodontal therapy with control (conventional scaling and root planning) following the concept of guided biofilm therapy (GBT) as an adjunctive to subgingival instrumentation (SI) in nonsurgical periodontal therapy for Stage II and III periodontitis patients both clinically and microbiologically.
Investigators
Diana Ibrahim
Periodontology MSc. Candidate
Alexandria University
Eligibility Criteria
Inclusion Criteria
- •Individuals of both sexes with an age between 30 and 65 years, having at least 16 natural teeth in function,
- •Stage II and III (moderate to severe) periodontitis, having at least 16 teeth with the need for SI
- •Interproximal plaque index (API) ≤ 35%; patients with Good oral hygiene.
- •No history of systemic disease that may influence periodontal disease
Exclusion Criteria
- •Pregnancy or breastfeeding,
- •Smokers with more than seven cigarettes per day
- •Patients that had a treatment with antibiotics within six months before the study
- •Need for periodontal surgery or adjunctive antibiotic treatment to the SI
- •Patients who had any periodontal treatment during the last year before the study.
- •Patients with known systemic or autoimmune disease.
Outcomes
Primary Outcomes
Bleeding on probing
Time Frame: up to six months
Plaque accumulation
Time Frame: up to six months
Pain Assessment
Time Frame: up to six months
Pain level will be assed using Visual Analogue Scale (VAS) from 1 (minimum) to 10 (maximum)
Probing depth
Time Frame: up to six months
Clinical attachment level
Time Frame: up to six months
Microbiological Assessment of Aggregatibacter actinomycetemcomitans (Aa)
Time Frame: one month
Microbiological Assessment of Porphyromonas gingivalis (Pg)
Time Frame: one month
Microbiological Assessment of Tannerella forsythia (Tf)
Time Frame: one month
Microbiological Assessment of Treponema denticola (Td)
Time Frame: one month