The Effect of Bovine Colostrum Supplementation in Older Adults
- Conditions
- SarcopeniaOsteoporosis
- Interventions
- Dietary Supplement: Bovine colostrumDietary Supplement: Whey protein
- Registration Number
- NCT01792297
- Lead Sponsor
- University of Saskatchewan
- Brief Summary
Bovine colostrum is the initial milk secreted by cows during the first day after calving. Colostrum is high in protein and contains a number of substances that have potential to be beneficial for the immune system. Preliminary studies about effects of colostrum supplementation show its potential for increasing human exercise performance; however, more evidence across the lifespan is required to confirm effects and to understand mechanisms of action. The objectives are to determine the effect of 8 weeks of bovine colostrum supplementation, compared to whey protein supplementation on the following dependent variables in men and women 50 years and older while participating in a resistance-training program:
* muscle mass
* strength
* blood levels of growth factors and markers of inflammation
* urine levels of muscle and bone catabolic markers
* tests of cognitive ability It is hypothesized that bovine colostrum supplementation will result in greater increases in muscle mass, strength, blood IGF-1 levels (an anabolic hormone), and cognitive ability, and greater reductions in inflammation, and markers of muscle and bone catabolism, compared to placebo.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
- Men or women 50 y or older
- Milk allergies
- Contraindications to exercise as indicated by the Physical Activity Readiness Questionnaire
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Bovine Colostrum Bovine colostrum 60 g/d bovine colostrum in powder form to be mixed with drinks. The dose will be spread out 3 times per day (20 g per dose) Whey protein Whey protein 60 g/d whey protein powder mixed into drinks. It is to be divided into 3 daily doses (20 g per dose)
- Primary Outcome Measures
Name Time Method change from baseline in lean tissue mass at 8 weeks baseline and 8 weeks Lean tissue mass assessed by dual energy x-ray absorptiometry
Change from baseline in Upper body strength at 8 weeks baseline and 8 weeks Bench Press Strength
Change from baseline in Lower body strength at 8 weeks baseline and 8 weeks Leg press strength
- Secondary Outcome Measures
Name Time Method Change from baseline in lower body muscle thickness at 8 weeks baseline and 8 weeks Knee extensors muscle thickness assessed by ultrasound
Change from baseline in muscle catabolism at 8 weeks baseline and 8 weeks Urinary 3-methylhistidine levels
Change from baseline in Insulin like growth factor-1 at 8 weeks baseline and 8 weeks IGF-1 from serum
Change from baseline in upper body muscle thickness at 8 weeks baseline and 8 weeks Muscle thickness of the elbow flexors assessed by ultrasound
Change from baseline in bone catabolism at 8 weeks Baseline and 8 weeks Urinary cross-linked N-telopeptides of type I collagen
Number of Participants with Adverse Events as a Measure of Safety and Number of Participants with Adverse Events as a Measure of Safety and Tolerability continuously throughout 8 weeks Adverse events collected on adverse event forms
Change from baseline in inflammation at 8 weeks baseline and 8 weeks Serum cytokine markers of inflammation (IL-6 and TNF-alpha)
Change from baseline in cognitive ability at 8 weeks baseline and 8 weeks The Telephone Interview of Cognitive Status
Trial Locations
- Locations (1)
College of Kinesiology, University of Saskatchewan
🇨🇦Saskatoon, Saskatchewan, Canada