DepoCyt Therapy in Patients With Neoplastic Meningitis From Lymphoma or a Solid Tumor
- Conditions
- Meningeal Neoplasms
- Registration Number
- NCT00029523
- Lead Sponsor
- Pacira Pharmaceuticals, Inc
- Brief Summary
The purpose of this study is to find out how well an experimental drug called DepoCyt works for neoplastic meningitis (cancer that has spread to the tissues around the brain and spinal cord). DepoCyt is a new slow-release form of the cancer drug called ara-C (cytarabine). Cytarabine has been used for many years to treat cancer.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Progression-free survival, defined as the time to neurological progression or death
- Secondary Outcome Measures
Name Time Method Time to neurological progression; Survival (all-cause and meningeal disease-specific) Frequency of improvement in pre-existing meningeal-disease related neurological deficits Karnofsky Performance Scores (KPS) Quality of life Cytological response rate Overall safety profile
Trial Locations
- Locations (23)
Straub Clinic and Hospital
🇺🇸Honolulu, Hawaii, United States
Georgetown University Medical Center Hematology/Oncology
🇺🇸Washington, District of Columbia, United States
Loyola University Medical Center, Dept. of Hematology/Oncology
🇺🇸Maywood, Illinois, United States
JFK Neuroscience Institute
🇺🇸Edison, New Jersey, United States
CancerCare Manitoba
🇨🇦Winnipeg, Manitoba, Canada
Mayo Clinic, Jacksonville
🇺🇸Jacksonville, Florida, United States
Barrow Neurological Institute
🇺🇸Phoenix, Arizona, United States
Alta Bates Comprehensive Cancer Center
🇺🇸Berkeley, California, United States
University of Southern California, Norris Cancer Center
🇺🇸Los Angeles, California, United States
University of Colorado Hospital, Anschutz Cancer Pavilion
🇺🇸Denver, Colorado, United States
H. Lee Moffitt Cancer Center and Research Institute
🇺🇸Tampa, Florida, United States
Emory Clinic, Department of Neurosurgery
🇺🇸Atlanta, Georgia, United States
Rush Cancer Institute
🇺🇸Chicago, Illinois, United States
Beth Israel Deaconess Medical Center Dept. of Neurology
🇺🇸Boston, Massachusetts, United States
Park Nicollet Institute, Oncology Research Program
🇺🇸Minneapolis, Minnesota, United States
University of Pittsburgh Cancer Institute
🇺🇸Pittsburgh, Pennsylvania, United States
Vanderbilt University Medical Center
🇺🇸Nashville, Tennessee, United States
University of Texas Health Science Center
🇺🇸San Antonio, Texas, United States
Toronto Sunnybrook Regional Cancer Center
🇨🇦Toronto, Ontario, Canada
Bowman Gray School of Medicine/Comprehensive Cancer Center of Wake Forest University
🇺🇸Winston-Salem, North Carolina, United States
Case Western Reserve University Hospital of Cleveland
🇺🇸Cleveland, Ohio, United States
University of Utah, Hunsman Cancer Institute
🇺🇸Salt lake City, Utah, United States
Virginia Mason Medical Center
🇺🇸Seattle, Washington, United States