Periventricular White Matter Hyperintensities in Cerebral Amyloid Angiopathy and Hypertensive Arteriopathy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 315
- 试验地点
- 1
- 主要终点
- Distribution of PVWMH
研究概览
简要总结
White matter hyperintensities (WMH) are one of the small vessel disease-related MRI characteristics of both cerebral amyloid angiopathy (CAA) and hypertensive arteriopathy (HA). WMH tend to show a peri-basal ganglia pattern in HA, whereas a multiple subcortical spots pattern can be observed in CAA. Periventricular WMH (PVWMH) have been reported to be posterior predominant using a semiautomated segmentation method and logarithmic transformation, not used in daily clinical practice. In these studies including CAA patients, patients initially presented with haemorrhage-related symptoms. In another study analysing PVWMH and cerebral amyloid evidence in patients with mild cognitive impairment, frontal PVWMH burden was associated with high uptake on florbetapir-PET whereas parietal and occipital PVWMH burden was associated with low CSF-amyloid-beta.
The aim of this study is the descriptive comparative analysis of the distribution of PVWMH between CAA and HA patients with radiological tools available in daily practice.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •CAA and HA patients, managed at Nîmes University Hospital between January 2015 and March 2022.
排除标准
- •CAA and HA patients, treated at the CHU of Nîmes between January 2015 and March 2022, not objecting to the use of their health data
结局指标
主要结局
Distribution of PVWMH
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Maximal distance between the outer PVWMH border and the border of the lateral ventricle (on the axis oriented at 90° to the border of the ventricle)
Distribution of PVWMH - total PVWMH extent.
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The sum of the PVWMH measurements around the four ventricles horns (i.e. bilateral anterior and posteriors horns) resulted in total PVWMH extent.
Corpus callosum (CC) WMH
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Distance between the border of the third ventricle and the outer border of the WMH on the rostro-caudal axis, resulting in anterior and posterior CC-PVWMH extent measurements.
Corpus callosum (CC) WMH - total CC-PVWMH extent.
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The sum of the anterior and posterior CC-PVWMH measurements resulted in the total CC-PVWMH extent.
Anterior PVWMH
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Comparison of anterior PVWMH between CAA group and HA group.
Posterior PVWMH
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Comparison of posterior PVWMH between CAA group and HA group.
Total PVWMH
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Comparison of total PVWMH between CAA group and HA group.
anterior CC-PVWMH
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Comparison of anterior CC-PVWMH between CAA group and HA group.
Total PVWMH and posterior/anterior CC-PVWMH ratio
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Comparison of total PVWMH and posterior/anterior CC-PVWMH ratio between CAA group and HA group.
Posterior/anterior PVWMH ratio
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Comparison of the posterior/anterior PVWMH ratio between CAA and HA groups.
Posterior CC-PVWMH
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Comparison of posterior CC-PVWMH between CAA group and HA group.
Ratios
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Calcul of posterior/anterior ratios for both the PVWMH and CC-PVWMH
次要结局
未报告次要终点