NL-OMON27211招募中不适用
Cerebrovascular reserve and white matter disease in patients with chronic anemia
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- AMC
- 入组人数
- 140
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •Patient group:
- •Sickle cell disease,
- •Thalassemia major, thalassemia intermedia, and HbH disease
- •18 years of age or older
- •Informed consent
- •Control Group:
- •Either AS or AA haemogobin
- •18 years of age or older
- •Informed consent
排除标准
- •Patient group:
- •Hospitalization in the past month for any reason
- •Inability of the patient to provide informed consent
- •Contraindications for MRI, such as claustrophobia or the presence of metal in the body
- •Sickle cell crisis at the moment of participation up to one month prior to participation
- •History of cerebral pathology that comprimized measeurements, such as cerebral palsy, brain tumour, meningitis, overt infrarct
- •Brain surgery performed in the last 3 months
- •ACZ contraindications
- •Severe liver, heart of renal dysfunction (clearance <10 mL/min)
- •Allgergy to sulphonamide
- •Pregnant or breastfeeding
- •Use of phenytoin, procaïne or acetylsacylic acid
- •Risk of hypokalaemia
- •Addison's disease
- •Severe asthma or emphysema
- •Control Group:
- •Any known chronic illness that may compromise subject safety or data integrity.
- •Vascular risk factors
- •Hypercholesterolemia
- •Contraindications for MRI
- •Contraindications for ACZ
- •Developmental delay, stroke, seizure disorder, or neurological conditions other than simple migraine
- •inability to cooperate with MRI examinations
- •Uncontrolled hypertension or history of hypertension
研究者
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