Investigation of Endemic and Emerging Diseases in Populations of Homeless Households in Marseille.

Not Applicable

Completed

• Conditions: Endemic and Emerging Diseases in Populations of Homeless
• Interventions: Other: Swabs skin, pharyngeal, and blood sample; Other: Collection of body lice

• Registration Number: NCT02819128
• Lead Sponsor: Assistance Publique Hopitaux De Marseille

Brief Summary

Hypothesis:

Homeless people have infections not diagnosed with a potential impact on their health status.

Main Purpose: Improve the etiological diagnosis of endemic and/or emerging pathologies among homeless people.

Detailed Description

In Marseilles, the population of homeless is estimated at 1500 individuals, including 800 usually sleeping in the street, 600 in foster homes and a hundred in the structures of care. The precarious living conditions of homeless persons promote the emergence or re-emergence of many communicable infectious diseases homeless people whose symptoms are often overlooked by the subject and rarely established etiologic diagnosis.

Among these diseases, frequently described in the literature are infestation by lice and infectious diseases that they transmit (Bartonella quintana), skin infections, hepatitis E and C and finally the infection with Tropheryma Whipplei. In this study we propose to systematically in homeless subject an etiological diagnosis of pathogens at the origin of these diseases (i) to improve knowledge (ii) to improve their management, (iii) to limit the contagion.

Study Timeline

• Study Start: 2014-01-25
• Study First Submitted: 2016-06-28
• Study First Submitted QC: 2016-06-28
• Study First Posted: 2016-06-30
• Primary Completion: 2020-09-30
• Study Completion: 2022-10-26
• Status Verified: 2023-04
• Last Update Submitted: 2023-04-20
• Last Update Posted: 2023-04-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 722

Inclusion Criteria

• Homeless Subject on the day of the study in one of two shelters for homeless Marseille ( Madrague City and Forbin )
• Major subject ( > or equal to 18 years)
• Freely about having signed the written informed consent,
• About affiliated with a social security scheme

Exclusion Criteria

• Minor Subjects ( < 18 years )
• Major subject under guardianship (L. 1121-8 )
• Subject privated of freedom or under court order (L. 1121-6 )
• Subject refusing to sign the informed consent form ,
• Subject not affiliated with a social security insurance
• Pregnant women , parturient or nursing (L. 1121-7 ) .

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Homeless people	Swabs skin, pharyngeal, and blood sample	Populations of homeless households in Marseille.
Homeless people	Collection of body lice	Populations of homeless households in Marseille.

Primary Outcome Measures

Name	Time	Method
Percentage of subjects with an established microbiological diagnosis	3 years

Secondary Outcome Measures

Name	Time	Method
Prevalence of infections by Bartonella quintana	1 day
Prevalence of infection by hepatitis E and C	1 day
Prevalence of Tropheryma whipplei infections	1 day
Percentage of body lice resistant to permethrin	1 day
Prevalence of skin infections	1 day
Prevalence of infestation by body lice	1 day

Trial Locations

Locations (1)

Assistance Publique Hopitaux de Marseille; 🇫🇷 Marseille, France