A randomized controlled trial on the effect of gastric-acid inhibiting drug on sleep bruxism and oral disease
Phase 1
- Conditions
- Sleep Bruxism
- Registration Number
- JPRN-UMIN000002923
- Lead Sponsor
- Department of Orthodontics, Kagoshima University Graduate School of Medical and Dental Sciences
- Brief Summary
The frequencies of EMG bursts, rhythmic masticatory muscle activity (RMMA) episodes, grinding noise, and the RMMA/microarousal ratio were significantly higher in the 20-min period after acidic infusion than after saline infusion. RMMA episodes including SB were induced by esophageal acidification.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- Male
- Target Recruitment
- 20
Inclusion Criteria
Not provided
Exclusion Criteria
1. Individual with secondary sleep bruxism 2. Individual with sleep disorder except sleep bruxism 3. Individual with gastro-intestinal disease 4. Individual with any medication within three months
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Frequency of sleep bruxism episodes 2. Masticatory muscle activity during sleep
- Secondary Outcome Measures
Name Time Method 1. Frequency of tooth grinding noises 2. Frequency of gastro-esophageal reflux episodes 3. Sleep-stage distribution 4. Frequency of micro-arousals 5. Gastrointestinal symptoms on awakening