Synchronous rTMS and Computer-integrated Speech Training Applied in Aphasic Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Stroke
- Sponsor
- Taipei Veterans General Hospital, Taiwan
- Enrollment
- 120
- Locations
- 1
- Primary Endpoint
- Change From Baseline in aphasia level on the Concise Chinese Aphasia Test (CCAT) at 2 Weeks
- Last Updated
- 5 years ago
Overview
Brief Summary
The refinement of repetitive transcranial magnetic stimulation (rTMS) has highlighted its merit in terms of learning programs as a treatment for aftereffect augmentation. Nevertheless, the efficacy of synchronous rTMS protocol integrated with computer-integrated speech training is not well understood. It is also not clear regarding the efficacy of compound bi-hemispheric stimulation protocol. The aim of the study is to investigate language response to these new strategies and to determine the longevity of the therapeutic outcome. Advanced MR neuroimaging techniques, such as fMRI and DTI, are powerful tools to evaluate the concomitant nervous changes after rTMS treatment on aphasic patients. The knowledge from fMRI and DTI microstructural evolution provides insight into underlined mechanism operating the language improvement.
Detailed Description
The efficacy of synchronous rTMS protocol integrated with computer-integrated speech training is not well understood. It is also not clear regarding the efficacy of inhibitory or excitatory stimulation protocol. The aim of the study is to investigate language response to these new strategies and to determine the longevity of the therapeutic outcome. Advanced MR neuroimaging techniques, such as fMRI and DTI, are powerful tools to evaluate the concomitant nervous changes after rTMS treatment on aphasic patients. The knowledge from fMRI and DTI microstructural evolution provides insight into underlined mechanism operating the language improvement
Investigators
vghtpe user
Principal investigator
Taipei Veterans General Hospital, Taiwan
Eligibility Criteria
Inclusion Criteria
- •Aphasic stroke in chronic stage (over 3 months)
Exclusion Criteria
- •No seizure history, no brain surgery history, no electronic device in brain or chest, no dementia
Outcomes
Primary Outcomes
Change From Baseline in aphasia level on the Concise Chinese Aphasia Test (CCAT) at 2 Weeks
Time Frame: Up to 12 weeks
linguistic function assessment
Secondary Outcomes
- Change from Baseline in the concomitant nervous status on the Functional magnetic resonance imaging (fMRI) at 2 weeks(Up to 12 weeks)