Platelet Rich Fibrin Versus Melatonin Around Dental Implants

Phase 2

Completed

• Conditions: Patients With Missing Teeth
• Interventions: Biological: dental implants with melatonin gel

• Registration Number: NCT05593731
• Lead Sponsor: Misr University for Science and Technology

Brief Summary

Dental implant is a dental treatment that allow oral rehabilitation for partial and fully edentulous patients. Osteointegration is the factor that control success s or failure of dental implant that can be improved by addition of different adjunctive biological materials. Platelets Rich fibrin plays a significant role in tissue regeneration and wound healing. Melatonin is biological hormone that secreted from pineal gland and played an important role in human growth.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-12-10
• Primary Completion: 2022-07-10
• Study Completion: 2022-08-10
• Study First Submitted: 2022-10-12
• Study First Submitted QC: 2022-10-23
• Study First Posted: 2022-10-25
• Status Verified: 2023-10
• Last Update Submitted: 2023-10-19
• Last Update Posted: 2023-10-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 30

Inclusion Criteria

1. good oral hygiene participants,
2. free of any systemic diseases,
3. Patients' age ranged from 20 to 40 years old.
4. Patients who can complete surgery and the study protocol.
5. Partially edentulous patients in the posterior mandibular region (at least a single-mandibular edentulous area) with periodontal health.

Exclusion Criteria

1. patients who had parafunctional habits,
2. current and former smokers, pregnant
3. lactating women
4. unmotivated patients
5. patients with psychological problems
6. patients who were not able to follow the treatment protocol -

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
dental implants alone	dental implants with melatonin gel	dental implants alone
platelet rich fibrin	dental implants with melatonin gel	dental implants with platelet rich fibrin membrane
melatonin gel	dental implants with melatonin gel	dental implants with melatonin gel around dental implants

Primary Outcome Measures

Name	Time	Method
gingival thickness	6 months

Secondary Outcome Measures

Name	Time	Method
marginal bone loss	6 months
bone density	6 months

Trial Locations

Locations (1)

Faculty of dentistry at MUST; 🇪🇬 Giza, Egypt