L-PRF in Alveolar Ridge Preservation

Not Applicable

Completed

• Conditions: Bone Loss, Alveolar
• Interventions: Procedure: Platelet-rich fibrin

• Registration Number: NCT03408418
• Lead Sponsor: Rio de Janeiro State University

Brief Summary

The effect of leucocyte- and platelet-rich fibrin (L-PRF) for enhancing the healing after dental extractions is still a matter of debate. The available literature suggests that L-PRF performs positive effect to improve alveolar preservation resulting in less bone resorption on extraction sockets. L-PRF is a second generation of platelet concentrate produced without biochemical blood manipulation. L-PRF is composed by three key parameters: first, the presence of platelets; second, the presence of leucocytes; third, the density and complex organization of the fibrin matrix architecture produced by a natural polymerization process. The theory is that this key parameters acts to produce a faster bone healing.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2018-01-16
• Study First Submitted QC: 2018-01-22
• Study First Posted: 2018-01-24
• Study Start: 2018-03-01
• Status Verified: 2019-03
• Primary Completion: 2019-03-01
• Study Completion: 2019-03-01
• Last Update Submitted: 2019-03-25
• Last Update Posted: 2019-03-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

• (1) Health patients, American Society of Anesthesiologists (ASA) I or II
• (2) Patients who need to submit tooth extraction (pre-molar, canine and incisor teeth - uniradicular teeth or teeth with fused roots) which present ideal conditions to receive dental implants after 3 months.

Exclusion Criteria

• Smoking
• Systemic diseases related with healing disorders
• Poor oral hygiene
• Pregnant or lactating patient
• Use of flap elevation for dental extraction

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
L-PRF group	Platelet-rich fibrin	The use of autologous leucocyte- and platelet-rich fibrin in alveolar sockets after dental extraction.

Primary Outcome Measures

Name	Time	Method
Width resorption 1mm	After 3 months	The ridge width differences between baseline and after three months of healing 1 mm below the crest.

Secondary Outcome Measures

Name	Time	Method
Histological Analysis - fibrous tissue	After 3 months	The percentage of soft (fibrous) tissue
Histological Analysis - bone cells	After 3 months	Quantity of bone cells (osteoblast, osteoclast and osteocyte)
Histological Analysis - capillary vessels	After 3 months	Quantity of capillary vessels
Histological Analysis - new bone formation	After 3 months	The percentage of the newly formed bone
Width resorption 3mm	After 3 months	The ridge width differences between baseline and after three months of healing 3 mm below the crest.
Width resorption 5mm	After 3 months	The ridge width differences between baseline and after three months of healing 5 mm below the crest.

Trial Locations

Locations (1)

Rio de Janeiro State University; 🇧🇷 Rio De Janeiro, Brazil