The anterior vs the posterolateral approach for THA: is there a difference in tissue damage?
- Conditions
- total hip arthroplasty (THA)
- Registration Number
- NL-OMON24737
- Lead Sponsor
- Dept. of OrthopaedicsMartini Hospital Groningen
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 46
Inclusion Criteria
1. Age between 18 and 90 years;
2. Indication for THA is primary or secondary symptomatic osteoarthritis.
Exclusion Criteria
1. A history of previous surgery on the ipsilateral hip;
2. Peripheral neuropathy;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Tissue damage will be assessed via the enumeration of the tissue macrophages in blood (over time), preferably also using specific antibodies against fragments of tissue-specific proteins, such as soft tissue and skeletal muscle. Multiparameter (≥ 8 colors) flow cytometry can accurately detect and identify the circulating tissue macrophages with a first set of antibodies against membrane markers. The absolute and relative numbers of the blood tissue macrophages during and after the THA procedure should be able to give insight into the extent of tissue damage in individual patients. In addition, the levels of serum creatine kinase (CK), creatine phosphokinase (CPK), and C-reactive protein (CRP) will be assessed.
- Secondary Outcome Measures
Name Time Method Besides a relative and quantitative assessment, the secondary study parameter will be the presence of bone- and muscle- specific protein fragments in the circulating macrophages. The presence of these fragments, might be related to the extent of bone and muscle damage, potentially allowing a more accurate assessment of damage caused by the different THA approaches.