Social Cognition in Ageing and in Frontotemporal Lobar Degeneration (Frontotemporal Dementia and Semantic Dementia): a Cognitive and Neuroimaging Study
试验速览
- 阶段
- 不适用
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Social cognition scores
研究概览
简要总结
The purpose of this study is to examine the age and the neurodegenerative disease effects on social cognition. Secondary goals are to better understand the relationships between different component of social cognition, executive functioning, and behavior and describing the neuronal substrates associated to the alteration of the social cognition in ageing and dementia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Factorial
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •All the participants
- •Age between 40 and 80 years
- •Minimum of 7 years of education
- •French native speaker
- •Healthy subjects
- •Non pathological Dementia rating scale score
- •Clinical diagnosis of frontotemporal lobar degeneration
排除标准
- •Chronic neurological disease
- •Encephalitis
- •Endocrinal disease
- •Hepatic disease
- •Case history of head injury with loss of consciousness of more than one hour
- •Case history of stroke
- •Case history of cancer during the five last years except squamous cell carcinomas
- •Alcoholism or drug addiction
- •Major psychiatric disorders according the Diagnostic and Statistical Manual of Mental Disorders
研究组 & 干预措施
Elderly
cognitive assessment and Brain imaging examination MRI of healthy elderly subjects
干预措施: Brain imaging examination MRI (Other)
Young
cognitive assessment and Brain imaging examination MRI of young subjects
干预措施: Cognitive assessment (Behavioral)
Young
cognitive assessment and Brain imaging examination MRI of young subjects
干预措施: Brain imaging examination MRI (Other)
Semantic demantia
cognitive assessment and Brain imaging examination MRI of patient with the semantic variant of primary progressive aphasia
干预措施: Brain imaging examination MRI (Other)
Elderly
cognitive assessment and Brain imaging examination MRI of healthy elderly subjects
干预措施: Cognitive assessment (Behavioral)
Semantic demantia
cognitive assessment and Brain imaging examination MRI of patient with the semantic variant of primary progressive aphasia
干预措施: Cognitive assessment (Behavioral)
Frontotemporal dementia
cognitive assessment and Brain imaging examination MRI of patients with the behavioral variant of frontotemporal lobar degeneration
干预措施: Cognitive assessment (Behavioral)
Frontotemporal dementia
cognitive assessment and Brain imaging examination MRI of patients with the behavioral variant of frontotemporal lobar degeneration
干预措施: Brain imaging examination MRI (Other)
结局指标
主要结局
Social cognition scores
时间窗: 2 years
number of correct responses in a social cognition test
次要结局
未报告次要终点