Cognitive Changes and Brain Connectivity in Age-Related Macular Degeneration
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Age-Related Macular Degeneration
- Sponsor
- Duke University
- Enrollment
- 238
- Locations
- 1
- Primary Endpoint
- Cognitive Changes and Brain Connectivity in Age-Related Macular Degeneration
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
This study is to determine how cognitive deficits (e.g.,verbal fluency deficit) in patients with Age-Related Macular Degeneration (AMD) relate to specific aspects of brain and function. The study team will assess whether the "brain signatures" associated with specific cognitive deficits differ in older adults with and without AMD.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Vision loss attributable to AMD
- •Age match (± 5 yrs)
- •Gender match
- •Education match (± 4yrs)
- •Normal macular exam
Exclusion Criteria
- •Other significant eye pathology
- •Mod/severe dementia
- •Communication barrier that precludes testing
- •Other significant eye pathology
- •Mod/severe dementia
- •Communication barrier that precludes testing
- •Devices or material incompatible with 3.0 Tesla MRI
- •Conditions that may interfere with interpretation of fMRI (e.g. history of stroke, brain tumor or previous brain surgery; psychoactive medications; seizure disorder)
- •Claustrophobia
- •Left-handed
Outcomes
Primary Outcomes
Cognitive Changes and Brain Connectivity in Age-Related Macular Degeneration
Time Frame: Baseline, anticipated 2 years
All Participants will receive neurocognitive testing, health and lifestyle surveys, audiometry and eye exams. Brain MRIs will be obtained on half the cohort, as this will provide sufficient power to accomplish the Aims that involve neuroimaging data. These MRIs will be obtained while participants are in the "resting state" meaning they are awake but not instructed to perform specific scanner. Two years after baseline exams, participants will return for repeat data collection. Participants who received an MRI at baseline will receive repeat resting-state, brain MRI at 2-year follow-up, unless they have developed contradictions to MRI scans in the interim.