Cognitive Mechanisms and Cerebral Substrate of Naming Impairment During Aging. Behavior and Neuroimaging Approaches.
Overview
- Phase
- Not Applicable
- Status
- Terminated
- Sponsor
- University Hospital, Grenoble
- Enrollment
- 33
- Locations
- 1
- Primary Endpoint
- Blood Oxygen Level Dependent functional MRI
Overview
Brief Summary
The purpose of this study is to understand the effect of age on language abilities. The investigators aim at investigating the cerebral modifications that take place in normal aging, at the functional an anatomical level.
Study Design
- Study Type
- Observational
- Observational Model
- Other
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 30 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Age of 30 years and above
- •Right handed
- •French native speakers
- •Affiliation to French social security (Sécurité Sociale)
- •Medical interview
- •Consent form signed
Exclusion Criteria
- •Cerebral or respiratory pathologies
- •Any MRI contrindication
Outcomes
Primary Outcomes
Blood Oxygen Level Dependent functional MRI
Time Frame: There will be a unique MRI measurement for each participant. Group analyses presentation after 1 year.
We use 3 functional tasks using block paradigm: Object naming, Verbal generation and semantic judgment, to elicit BOLD response using fMRI in order to compare functional activation patterns between subjects. We also use hypercapnic challenge to elicit BOLD response in order to obtain Cerebral Vascular Reactivity properties of subjects.
Anatomical MRI
Time Frame: There will be a unique MRI measurement for each participant. Group analyses presentation after 1 year.
We use Voxel Based Morphometry to compare cortical volume (grey matter) between subjects. We also use tractography Diffusion Tensor Imaging to compare white matter properties between subjects.
Secondary Outcomes
No secondary outcomes reported