Cognitive Mechanisms and Cerebral Substrate of Naming Impairment During Aging. Behavior and Neuroimaging Approaches.
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 33
- 试验地点
- 1
- 主要终点
- Blood Oxygen Level Dependent functional MRI
研究概览
简要总结
The purpose of this study is to understand the effect of age on language abilities. The investigators aim at investigating the cerebral modifications that take place in normal aging, at the functional an anatomical level.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age of 30 years and above
- •Right handed
- •French native speakers
- •Affiliation to French social security (Sécurité Sociale)
- •Medical interview
- •Consent form signed
排除标准
- •Cerebral or respiratory pathologies
- •Any MRI contrindication
结局指标
主要结局
Blood Oxygen Level Dependent functional MRI
时间窗: There will be a unique MRI measurement for each participant. Group analyses presentation after 1 year.
We use 3 functional tasks using block paradigm: Object naming, Verbal generation and semantic judgment, to elicit BOLD response using fMRI in order to compare functional activation patterns between subjects. We also use hypercapnic challenge to elicit BOLD response in order to obtain Cerebral Vascular Reactivity properties of subjects.
Anatomical MRI
时间窗: There will be a unique MRI measurement for each participant. Group analyses presentation after 1 year.
We use Voxel Based Morphometry to compare cortical volume (grey matter) between subjects. We also use tractography Diffusion Tensor Imaging to compare white matter properties between subjects.
次要结局
未报告次要终点