Social Cognition in Ageing and in Frontotemporal Lobar Degeneration

Not Applicable

• Conditions: Frontotemporal Lobar Degeneration; Aging
• Interventions: Behavioral: Cognitive assessment; Other: Brain imaging examination MRI

• Registration Number: NCT01962064
• Lead Sponsor: University Hospital, Caen

Brief Summary

The purpose of this study is to examine the age and the neurodegenerative disease effects on social cognition. Secondary goals are to better understand the relationships between different component of social cognition, executive functioning, and behavior and describing the neuronal substrates associated to the alteration of the social cognition in ageing and dementia.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-06
• Study First Submitted: 2013-09-03
• Status Verified: 2013-10
• Study First Submitted QC: 2013-10-10
• Last Update Submitted: 2013-10-10
• Study First Posted: 2013-10-14
• Last Update Posted: 2013-10-14
• Primary Completion: 2014-07
• Study Completion: 2014-11

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• All the participants

  • Age between 40 and 80 years
  • Minimum of 7 years of education
  • French native speaker

• Healthy subjects

  • Non pathological Dementia rating scale score

• Patients

  • Clinical diagnosis of frontotemporal lobar degeneration

Exclusion Criteria

• Chronic neurological disease
• Encephalitis
• Endocrinal disease
• Hepatic disease
• Case history of head injury with loss of consciousness of more than one hour
• Case history of stroke
• Case history of cancer during the five last years except squamous cell carcinomas
• Alcoholism or drug addiction
• Major psychiatric disorders according the Diagnostic and Statistical Manual of Mental Disorders

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
Semantic demantia	Cognitive assessment	cognitive assessment and Brain imaging examination MRI of patient with the semantic variant of primary progressive aphasia
Frontotemporal dementia	Brain imaging examination MRI	cognitive assessment and Brain imaging examination MRI of patients with the behavioral variant of frontotemporal lobar degeneration
Elderly	Cognitive assessment	cognitive assessment and Brain imaging examination MRI of healthy elderly subjects
Elderly	Brain imaging examination MRI	cognitive assessment and Brain imaging examination MRI of healthy elderly subjects
Young	Cognitive assessment	cognitive assessment and Brain imaging examination MRI of young subjects
Young	Brain imaging examination MRI	cognitive assessment and Brain imaging examination MRI of young subjects
Semantic demantia	Brain imaging examination MRI	cognitive assessment and Brain imaging examination MRI of patient with the semantic variant of primary progressive aphasia
Frontotemporal dementia	Cognitive assessment	cognitive assessment and Brain imaging examination MRI of patients with the behavioral variant of frontotemporal lobar degeneration

Primary Outcome Measures

Name	Time	Method
Social cognition scores	2 years	number of correct responses in a social cognition test

Trial Locations

Locations (1)

Inserm - EPHE - University of Caen U1077; 🇫🇷 Caen, France