Efficacy of Dengue Infection With Warning Signs Treated With Dexamethasone (DengDex Study)
- Registration Number
- NCT05631405
- Lead Sponsor
- Chulalongkorn University
- Brief Summary
The goal of this randomized double-blinded placebo-controlled trial is to learn about dexamethasone and the treatment of severe dengue population. The main question it aims to answer are steroid therapy may be effective in dengue.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
- Laboratory confirmed Dengue infected patients (Positive NS1 Ag or anti-DENV IgM by Dengue Duo test)
- And still in febrile phase (Body temp>37.5 C)
- Shock : Sys<90mmHg or Narrow PP (<20mmHg) orTachycardia (pulse>100/min) with Hematocrit decreased ≥20 %
- Fluid accumulation and respiratory distress
- Severe bleeding
- Severe organ involvement
Exclusion Criteria
- Severe dengue> 24 hrs
- Dengue without warning signs
- Pregnancy
- Patient who receieved any steroid within 1 week
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo - Intervention Dexamethasone -
- Primary Outcome Measures
Name Time Method Mortality 28 days The use of steroids in dengue will reduce mortality in rate
- Secondary Outcome Measures
Name Time Method Length of hospital stay 28 days The use of steroids in dengue will reduce Length of hospital stay in day
Trial Locations
- Locations (2)
Chulalongkorn University
🇹🇭Bangkok, Thailand
King Chulalongkorn Memorial Hospital
🇹🇭Bangkok, Thailand